Professor Christopher Cooper

-
Email
ccooper@essex.ac.uk -
Location
ESA.3.32, Colchester Campus
Teaching and supervision
Previous supervision

Degree subject: Sport and Exercise Science
Degree type: Doctor of Philosophy
Awarded date: 28/9/2020

Degree subject: Sport and Exercise Science
Degree type: Doctor of Philosophy
Awarded date: 29/6/2015

Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 5/7/2013

Degree subject: Sport and Exercise Science
Degree type: Master of Science (by Dissertation)
Awarded date: 3/7/2013

Degree subject: Sport and Exercise Science
Degree type: Master of Science (by Dissertation)
Awarded date: 3/7/2013

Degree subject: Sport and Exercise Science
Degree type: Doctor of Philosophy
Awarded date: 19/12/2012
Publications
Publications (1)
Highton, D., Caldwell, M., Tachtsidis, I., Elwell, CE., Smith, M. and Cooper, CE., (2023). The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling
Journal articles (232)
Jones, B., Waterworth, S., Rogerson, M., ANDREU-PEREZ, J., Moran, J., Cooper, C., Adams, T., Hope, E., Singh, J., Neary, P., Perrett, J. and Jamalifrard, M., (2025). Cerebral haemodynamic assessment following sport-related concussion (mild traumatic brain injury) in youth and amateur rugby union players. Sports Medicine - Open. 11 (1), 47-
McManus, C., Butson, J., Rogerson, M., Waterworth, S., Jones, B., Cooper, C. and Sandercock, G., (2024). . International Journal of Sports Science and Coaching. 19 (1), 401-409
Highton, D., Caldwell, M., Tachtsidis, I., Elwell, CE., Smith, M. and Cooper, CE., (2024). The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling. Biology Open. 13 (1), bio060087-
Jones, B., Waterworth, S., Tallent, J., Rogerson, M., Morton, C., Moran, J., Southall-Edwards, R., Cooper, C. and McManus, C., (2024). . Journal of Athletic Training. 59 (3), 317-324
Cooper, CE., Simons, M., Dyson, A., Leiva Eriksson, N., Silkstone, GGA., Syrett, N., Allen-Baume, V., B眉low, L., Ronda, L., Mozzarelli, A., Singer, M. and Reeder, BJ., (2024). Taming hemoglobin chemistry鈥攁 new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation. Experimental & Molecular Medicine. 56 (10), 2260-2270
McManus, C., Cooper, C. and Sandercock, G., (2023). . International Journal of Sports Science and Coaching. 18 (3), 793-800
Butson, J., McManus, C., Waterworth, S., Cooper, C. and Jones, B., (2023). . Asian Exercise and Sport Science Journal. 7 (1), 64-71
Cooper, CE., Bird, M., Sheng, X., Choi, J-W., Silkstone, GGA., Simons, M., Syrett, N., Piano, R., Ronda, L., Bettati, S., Paredi, G., Mozzarelli, A. and Reeder, BJ., (2021). . Frontiers in Chemistry. 9, 707797-
Cooper, CE., Silkstone, GGA., Simons, M., Gretton, S., Rajagopal, BS., Allen-Baume, V., Syrett, N., Shaik, T., Popa, G., Sheng, X., Bird, M., Choi, J-W., Piano, R., Ronda, L., Bettati, S., Paredi, G., Mozzarelli, A. and Reeder, BJ., (2020). . Biomaterials Science. 8 (14), 3896-3906
Cooper, CE., Silkstone, GGA., Simons, M., Rajagopal, B., Syrett, N., Shaik, T., Gretton, S., Welbourn, E., B眉low, L., Eriksson, NL., Ronda, L., Mozzarelli, A., Eke, A., Mathe, D. and Reeder, BJ., (2019). . Free Radical Biology and Medicine. 134, 106-118
Jones, B., Parry, D. and Cooper, CE., (2018). . PeerJ. 6 (4), e4393-e4393
Mcmanus, CJ., Cooper, CE. and Collison, J., (2018). . Journal of Biomedical Optics. 23 (1), 1-1
Simons, M., Gretton, S., Silkstone, GG., Rajagopal, BS., Allen-Baume, V., Syrett, N., Shaik, T., Eriksson, N., Ronda, L., Mozzarelli, A., Strader, MB., Alayash, AI., Reeder, BJ. and Cooper, CE., (2018). . Bioscience Reports. 38 (4), BSR20180370-
Alomari, EAM., Ronda, L., Bruno, S., Paredi, G., Marchetti, M., Bettati, S., Olivari, D., Fumagalli, F., Novelli, D., Ristagno, G., Latini, R., Cooper, CE., Reeder, BJ. and Mozzarelli, A., (2018). . Free Radical Biology and Medicine. 124, 299-310
Gheorghiev, MD., Hosseini, F., Moran, J. and Cooper, CE., (2018). . Sports Medicine - Open. 4 (44), 44-
Welbourn, EM., Wilson, MT., Yusof, A., Metodiev, MV. and Cooper, CE., (2017). . Free Radical Biology and Medicine. 103, 95-106
Silkstone, RS., Silkstone, G., Baath, JA., Rajagopal, B., Nicholls, P., Reeder, BJ., Ronda, L., Bulow, L. and Cooper, CE., (2016). . Advances in Experimental Medicine and Biology. 876, 455-460
Hettinga, FJ., Konings, MJ. and Cooper, CE., (2016). . Frontiers in Physiology. 7 (619), 619-
Jones, B. and Cooper, CE., (2016). . Advances in Experimental Medicine and Biology. 876, 35-40
Silkstone, GGA., Silkstone, RS., Wilson, MT., Simons, M., B眉low, L., Kallberg, K., Ratanasopa, K., Ronda, L., Mozzarelli, A., Reeder, BJ. and Cooper, CE., (2016). . Biochemical Journal. 473 (19), 3371-3383
Rong, Z. and Cooper, CE., (2016). . Advances in Experimental Medicine and Biology. 876, 121-127
Jones, B., Hamilton, DK. and Cooper, CE., (2015). . PLOS ONE. 10 (3), e0120338-e0120338
Silaghi-Dumitrescu, R., Scurtu, F., Mason, MG., Svistunenko, DA., Wilson, MT. and Cooper, CE., (2015). . Inorganica Chimica Acta. 436, 179-183
Caldwell, M., Moroz, T., Hapuarachchi, T., Bainbridge, A., Robertson, NJ., Cooper, CE. and Tachtsidis, I., (2015). . PLOS ONE. 10 (10), e0140171-e0140171
Cooper, C., (2015). Is artificial blood safe for vampires to eat?. Biochemist. 37 (6), 10-13
Deli, MA., Caldwell, M., Moroz, T., Hapuarachchi, T., Bainbridge, A., Robertson, NJ., Cooper, CE. and Tachtsidis, I., (2015). Modelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia. PloS One. 10 (10), creators-Cooper=3AChristopher_E=3A=3A
Jones, B., Hamilton, DK. and Cooper, CE., (2015). Muscle oxygen changes following sprint interval cycling training in elite field hockey players. PLoS ONE. 10 (3), creators-Cooper=3AChristopher_E=3A=3A
Mason, MG., Nicholls, P. and Cooper, CE., (2014). . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837 (11), 1882-1891
Jones, B. and Cooper, CE., (2014). . Advances in Experimental Medicine and Biology. 812, 333-339
Jones, B., Dat, M. and Cooper, CE., (2014). . Journal of Biomedical Optics. 19 (12), 127002-127002
Silaghi-Dumitrescu, R., Svistunenko, DA., Cioloboc, D., Bischin, C., Scurtu, F. and Cooper, CE., (2014). . Nitric Oxide: Biology and Chemistry. 42, 32-39
Kolyva, C., Ghosh, A., Tachtsidis, I., Highton, D., Cooper, CE., Smith, M. and Elwell, CE., (2014). . NeuroImage. 85 (Pt 1), 234-244
Cooper, CE., (2014). The chemiosmotic theory. Biochemist. 36 (4), 23-24
Nicholls, P., Marshall, DCA., Cooper, CE. and Wilson, MT., (2014). . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837, creators-Wilson=3AMichael_T=3A=3A
Jones, B., Dat, M. and Cooper, CE., (2014). Underwater near-infrared spectroscopy measurements of muscle oxygenation: laboratory validation and preliminary observations in swimmers and triathletes. Journal of Biomedical Optics. 19 (12), creators-Cooper=3AChristopher_E=3A=3A
Cooper, CE., Schaer, DJ., Buehler, PW., Wilson, MT., Reeder, BJ., Silkstone, G., Svistunenko, DA., Bulow, L. and Alayash, AI., (2013). . Antioxidants & Redox Signaling. 18 (17), 2264-2273
Rong, Z. and Cooper, CE., (2013). . Advances in Experimental Medicine and Biology. 789, 361-368
Rong, Z., Banaji, M., Moroz, T. and Cooper, CE., (2013). Can Mitochondrial Cytochrome Oxidase Mediate Hypoxic Vasodilation Via Nitric Oxide Metabolism?. OXYGEN TRANSPORT TO TISSUE XXXIV. 765, 231-238
Rong, Z., Wilson, MT. and Cooper, CE., (2013). . Nitric Oxide. 33, 74-80
Nicholls, P., Marshall, DC., Cooper, CE. and Wilson, MT., (2013). . Biochemical Society Transactions. 41 (5), 1312-1316
Jones, B., Hesford, CM. and Cooper, CE., (2013). . Advances in Experimental Medicine and Biology. 789, 185-191
Hesford, C., Cardinale, M., Laing, S. and Cooper, CE., (2013). . OXYGEN TRANSPORT TO TISSUE XXXIV. 765, 81-86
Hesford, CM., Laing, S. and Cooper, CE., (2013). . Advances in Experimental Medicine and Biology. 789, 179-184
HESFORD, CM., LAING, S., CARDINALE, M. and COOPER, CE., (2013). . Medicine & Science in Sports & Exercise. 45 (1), 83-92
Rong, Z., Alayash, AI., Wilson, MT. and Cooper, CE., (2013). . Nitric Oxide. 35, 193-198
Kadiiska, MB., Basu, S., Brot, N., Cooper, C., Saari Csallany, A., Davies, MJ., George, MM., Murray, DM., Jackson Roberts, L., Shigenaga, MK., Sohal, RS., Stocker, R., Van Thiel, DH., Wiswedel, I., Hatch, GE. and Mason, RP., (2013). . Free Radical Biology and Medicine. 61, 408-415
Cooper, CE., Schaer, DJ., Buehler, PW., Wilson, MT., Reeder, BJ., Silkstone, G., Svistunenko, DA., Bulow, L. and Alayash, AI., (2013). Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine 尾145. Antioxidants & Redox Signaling. 18 (17), 2264-2273
Silkstone, RS., Mason, MG., Nicholls, P. and Cooper, CE., (2012). Nitrogen dioxide oxidizes mitochondrial cytochrome c. Free Radical Biology and Medicine. 52 (1), 80-87
Coutts, LV., Cooper, CE., Elwell, CE. and Wilkins, AJ., (2012). . Cephalalgia. 32 (8), 621-629
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2012). . Journal of the American Chemical Society. 134 (18), 7741-7749
HESFORD, CM., LAING, SJ., CARDINALE, M. and COOPER, CE., (2012). . Medicine & Science in Sports & Exercise. 44 (3), 501-508
Wittekind, A., Cooper, CE., Elwell, CE., Leung, TS. and Beneke, R., (2012). . European Journal of Applied Physiology. 112 (8), 3129-3139
Jelfs, B., Banaji, M., Tachtsidis, I., Cooper, CE. and Elwell, CE., (2012). . PLoS ONE. 7 (6), e38297-e38297
Silaghi-Dumitrescu, R., Mich, M., Matyas, C. and Cooper, CE., (2012). Nitrite and nitrate reduction by molybdenum centers of the nitrate reductase type: Computational predictions on the catalytic mechanism. Nitric Oxide. 26 (1), 27-31
Kolyva, C., Tachtsidis, I., Ghosh, A., Moroz, T., Cooper, CE., Smith, M. and Elwell, CE., (2012). . Biomedical Optics Express. 3 (10), 2550-2550
Moroz, T., Banaji, M., Robertson, NJ., Cooper, CE. and Tachtsidis, I., (2012). . Journal of The Royal Society Interface. 9 (72), 1499-1509
Cooper, C., (2012). . The Lancet. 380 (9836), 21-22
Cooper, C., (2012). Run, swim, throw, cheat: The future of drugs in sport. The Biochemist. 34 (3), 34-39
Coles, JA., Jelfs, B., Banaji, M., Tachtsidis, I., Cooper, CE. and Elwell, CE., (2012). Modelling Noninvasively Measured Cerebral Signals during a Hypoxemia Challenge: Steps towards Individualised Modelling. PloS One. 7 (6), creators-Cooper=3AChristopher_E=3A=3A
Marshall, DCA., Nicholls, P., Wilson, MT. and Cooper, CE., (2012). . Nitric Oxide: Biology and Chemistry. 27, S11-S12
Rong, Z., Wilson, MT. and Cooper, CE., (2012). . Nitric Oxide: Biology and Chemistry. 27, creators-Wilson=3AMichael_T=3A=3A
Elwell, CE. and Cooper, CE., (2011). Making light work: illuminating the future of biomedical optics. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 369 (1955), 4358-4379
Elwell, CE., Boas, DA., Cooper, CE., Delpy, D., Ferrari, M., Quaresima, V. and Yodh, AG., (2011). Britton Chance 1913鈥2010. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 369 (1955), 4380-4389
Bischin, C., Deac, F., Silaghi-Dumitrescu, R., Worrall, JAR., Rajagopal, BS., Damian, G. and Cooper, CE., (2011). . Free Radical Research. 45 (4), 439-444
Cooper, CE., Penfold, S-M., Elwell, CE. and Angus, C., (2010). . Advances in Experimental Medicine and Biology. 662, 177-181
Banaji, M., Mallet, A., Elwell, CE., Nicholls, P., Tachtsidis, I., Smith, M. and Cooper, CE., (2010). . Advances in Experimental Medicine and Biology. 662, 285-291
Binzoni, T., Cooper, CE., Wittekind, AL., Beneke, R., Elwell, CE., Van De Ville, D. and Leung, TS., (2010). . Physiological Measurement. 31 (9), 1257-1269
Hesford, C., Cooper, CE. and Cardinale, M., (2010). Near Infrared Spectroscopy Measurements Of Muscle Metabolism In Elite Short-track Speed Skaters During On-ice Race Simulation. Medicine And Science In Sports And Exercise. 42 (5, 1), creators-Cooper=3AChristopher_E=3A=3A
Cooper, CE., Holladay, R., Nicholls, P., Svistunenko, DA., Mason, MG., Silkstone, G. and Wilson, MT., (2010). . Free Radical Biology And Medicine. 49 (1), creators-Wilson=3AMichael_T=3A=3A
Cooper, CE., (2009). . Artificial Organs. 33 (2), 110-114
Cooper, CE., Sharpe, MA., Mason, MG. and Nicholls, P., (2009). . Advances in Experimental Medicine and Biology. 645, 123-128
Cooper, CE., Cope, M., Elwell, CE. and Delpy, DT., (2009). . Advances in Experimental Medicine and Biology. 645, 129-134
Mason, MG., Nicholls, P. and Cooper, CE., (2009). . Biochemical Journal. 422 (2), 237-246
Mason, MG., Shepherd, M., Nicholls, P., Dobbin, PS., Dodsworth, KS., Poole, RK. and Cooper, CE., (2009). . Nature Chemical Biology. 5 (2), 94-96
Gaucher-Di Stasio, C., Paternotte, E., Prin-Mathieu, C., Reeder, BJ., Poitevin, G., Labrude, P., Stoltz, J-F., Cooper, CE. and Menu, P., (2009). . Biomaterials. 30 (4), 445-451
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2009). Engineering Electron Transfer Pathways in Myoglobin and Hemoglobin: A Route to Detoxify Blood Substitutes?. Free Radical Biology And Medicine. 47, creators-Wilson=3AMichael_T=3A=3A
Cooper, CE. and Brown, GC., (2008). . Journal of Bioenergetics and Biomembranes. 40 (5), 533-539
Cooper, CE., Mason, MG. and Nicholls, P., (2008). . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777 (7-8), 867-876
Cooper, CE., Silaghi-Dumitrescu, R., Rukengwa, M., Alayash, AI. and Buehler, PW., (2008). . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784 (10), 1415-1420
Cooper, CE., (2008). . Essays in Biochemistry. 44, 1-10
Cooper, CE., (2008). . Essays in Biochemistry. 44, 63-84
Mason, MG., Holladay, RS., Nicholls, P., Shepherd, M. and Cooper, CE., (2008). . GLOBINS AND OTHER NITRIC OXIDE-REACTIVE PROTEINS, PART B. 437, 135-159
Banaji, M., Mallet, A., Elwell, CE., Nicholls, P. and Cooper, CE., (2008). . PLoS Computational Biology. 4 (11), e1000212-e1000212
Reeder, BJ., Grey, M., Silaghi-Dumitrescu, R-L., Svistunenko, DA., B眉low, L., Cooper, CE. and Wilson, MT., (2008). . Journal of Biological Chemistry. 283 (45), 30780-30787
Cooper, C. and Beneke, R., (2008). Essays in Biochemistry: Preface. Essays in Biochemistry. 44
Cooper, C., Silkstone, G., Mason, M., Nicholls, P. and Wilson, M., (2008). . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777, S57-S58
Nicholls, P. and Cooper, CE., (2008). Does cytochrome c oxidase pump protons in the controlled state?. Biochimica Et Biophysica Acta-Bioenergetics. 1777 (S), creators-Cooper=3AChristopher_E=3A=3A
Nicholls, P. and Cooper, CE., (2008). Does cytochrome c oxidase pump protons in the controlled state?. Biochimica et Biophysica Acta - Bioenergetics. 1777 (S), creators-Cooper=3AChristopher_E=3A=3A
Cooper, CE., (2008). Drugs and ergogenic aids to improve sport performance.. Essays in biochemistry. 44, 1-10
Cooper, CE., Silkstone, G., Mason, MG., Nicholls, P. and Wilson, MT., (2008). Interactions of nitric oxide with cytochrome c and cytochrome c oxidase. Biochimica et Biophysica Acta: Bioenergetics. 1777, S57-S58
Mason, MG., Nicholls, P. and Cooper, CE., (2008). Steady state redox interactions of cytochrome c oxidase. Biochimica et Biophysica Acta - Bioenergetics. 1777 (S), creators-Cooper=3AChristopher_E=3A=3A
Banaji, M., Mallet, A., Elwell, CE., Nicholls, P. and Cooper, CE., (2008). A model of brain circulation and metabolism: NIRS signal changes during physiological challenges.. PLoS computational biology. 4 (11), creators-Cooper=3AChristopher_E=3A=3A
Cooper, CE. and Giulivi, C., (2007). Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology. American Journal of Physiology-Cell Physiology. 292 (6), C1993-C2003
Svistunenko, DA., Reeder, BJ., Wankasi, MM., Silaghi-Dumitrescu, R-L., Cooper, CE., Rinaldo, S., Cutruzzol?, F. and Wilson, MT., (2007). Reaction of Aplysia limacina metmyoglobin with hydrogen peroxide. Dalton Transactions (8), 840-840
Silaghi-Dumitrescu, R., Reeder, BJ., Nicholls, P., Cooper, CE. and Wilson, MT., (2007). Ferryl haem protonation gates peroxidatic reactivity in globins. Biochemical Journal. 403 (3), 391-395
Pipirou, Z., Bottrill, AR., Svistunenko, DA., Efimov, I., Basran, J., Mistry, SC., Cooper, CE. and Raven, EL., (2007). The Reactivity of Heme in Biological Systems:鈥 Autocatalytic Formation of Both Tyrosine鈭扝eme and Tryptophan鈭扝eme Covalent Links in a Single Protein Architecture. Biochemistry. 46 (46), 13269-13278
Tachtsidis, I., Tisdall, M., Leung, TS., Cooper, CE., Delpy, DT., Smith, M. and Elwell, CE., (2007). Investigation ofin vivomeasurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension. Physiological Measurement. 28 (2), 199-211
Griffin, M., Prior, D., Cooper, CE., Wilkins, AJ. and Elwell, CE., (2006). Near Infrared Spectroscopy as a Non-Invasive Assessment of Cortical Abnormality in Migraine?. Advances in Experimental Medicine and Biology. 578, 203-208
Cooper, CE., Pryor, D., Hall, C. and Griffin, M., (2006). NIRS-Detected Changes in the Motor Cortex During Mental Rehearsal of Physical Activity (Imaginary Exercise). Advances in Experimental Medicine and Biology. 578, 185-190
Cooper, CE., Blannin, M., Hall, C. and Griffin, M., (2006). NIRS-Detected Changes in the Arm During Mental Rehearsal of Physical Activity (Imaginary Exercise). Advances in Experimental Medicine and Biology. 578, 191-196
Mason, MG., Nicholls, P., Wilson, MT. and Cooper, CE., (2006). Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochromecoxidase. Proceedings of the National Academy of Sciences. 103 (3), 708-713
Dunne, J., Caron, A., Menu, P., Alayash, AI., Buehler, PW., Wilson, MT., Silaghi-Dumitrescu, R., Faivre, B. and Cooper, CE., (2006). Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochemical Journal. 399 (3), 513-524
Svistunenko, DA., Davies, N., Brealey, D., Singer, M. and Cooper, CE., (2006). Mitochondrial dysfunction in patients with severe sepsis: An EPR interrogation of individual respiratory chain components. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757 (4), 262-272
Giulivi, C., Kato, K. and Cooper, CE., (2006). Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology. American Journal of Physiology-Cell Physiology. 291 (6), C1225-C1231
VOLLAARD, NBJ., COOPER, CE. and SHEARMAN, JP., (2006). Exercise-Induced Oxidative Stress in Overload Training and Tapering. Medicine & Science in Sports & Exercise. 38 (7), 1335-1341
Griffin, M., Prior, D., Cooper, CE., Wilkins, AJ. and Elwell, CE., (2006). Near infrared spectroscopy as a noninvasive assessment of cortical abnormality in migraine?. Advances in experimental medicine and biology. 578, 203-208
Cooper, CE., Blannin, M., Hall, C. and Griffin, M., (2006). NIRS-detected changes in the arm during mental rehearsal of physical activity (imaginary exercise).. Advances in experimental medicine and biology. 578, 191-196
Cooper, CE., Pryor, D., Hall, C. and Griffin, M., (2006). NIRS-detected changes in the motor cortex during mental rehearsal of physical activity (imaginary exercise).. Advances in experimental medicine and biology. 578, 185-190
Myers, DE., Cooper, CE., Beilman, GJ., Mowlem, JD., Anderson, LAD., Seifert, RP. and Ortner, JP., (2006). A wide gap second derivative NIR spectroscopic method for measuring tissue hemoglobin oxygen saturation.. Advances in experimental medicine and biology. 578, 217-222
Cooper, C., Crowther, T., Smith, BM., Isaac, S. and Collin, HA., (2006). Assessment of the response of carrot somaclones to Pythium violae, causal agent of cavity spot. Plant Pathology. 55 (3), 427-432
Cooper, CE., Jurd, M., Nicholls, P., Wankasi, MM., Svistunenko, DA., Reeder, BJ. and Wilson, MT., (2005). On the formation, nature, stability and biological relevance of the primary reaction intermediates of myoglobins with hydrogen peroxide. Dalton Transactions (21), 3483-3483
Silaghi-Dumitrescu, R. and Cooper, CE., (2005). Transient species involved in catalytic dioxygen/peroxide activation by hemoproteins: possible involvement of protonated Compound I species. Dalton Transactions (21), 3477-3477
Silkstone, GG., Cooper, CE., Svistunenko, D. and Wilson, MT., (2005). EPR and Optical Spectroscopic Studies of Met80X Mutants of Yeast Ferricytochrome c. Models for Intermediates in the Alkaline Transition. Journal of the American Chemical Society. 127 (1), 92-99
Vollaard, NBJ., Reeder, BJ., Shearman, JP., Menu, P., Wilson, MT. and Cooper, CE., (2005). A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo. Free Radical Biology and Medicine. 39 (9), 1216-1228
Davies, NA., Brealey, DA., Stidwill, R., Singer, M., Svistunenko, DA. and Cooper, CE., (2005). Nitrosyl heme production compared in endotoxemic and hemorrhagic shock. Free Radical Biology and Medicine. 38 (1), 41-49
Vollaard, NBJ., Shearman, JP. and Cooper, CE., (2005). Exercise-Induced Oxidative Stress. Sports Medicine. 35 (12), 1045-1062
Myers, DE., Anderson, LD., Seifert, RP., Ortner, JP., Cooper, CE., Beilman, GJ. and Mowlem, JD., (2005). Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy. Journal of Biomedical Optics. 10 (3), 034017-034017
Svistunenko, DA. and Cooper, CE., (2004). A New Method of Identifying the Site of Tyrosyl Radicals in Proteins. Biophysical Journal. 87 (1), 582-595
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2004). The Radical and Redox Chemistry of Myoglobin and Hemoglobin: From<I> In Vitro</I> Studies to Human Pathology. Antioxidants and Redox Signaling. 6 (6), 954-966
Svistunenko, DA., Wilson, MT. and Cooper, CE., (2004). Tryptophan or tyrosine? On the nature of the amino acid radical formed following hydrogen peroxide treatment of cytochrome c oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1655 (1-3), 372-380
Vanin, AF., Svistunenko, DA., Mikoyan, VD., Serezhenkov, VA., Fryer, MJ., Baker, NR. and Cooper, CE., (2004). Endogenous Superoxide Production and the Nitrite/Nitrate Ratio Control the Concentration of Bioavailable Free Nitric Oxide in Leaves. Journal of Biological Chemistry. 279 (23), 24100-24107
Malone, SA., Lewin, A., Kilic, MA., Svistunenko, DA., Cooper, CE., Wilson, MT., Le Brun, NE., Spiro, S. and Moore, GR., (2004). Protein-Template-Driven Formation of Polynuclear Iron Species. Journal of the American Chemical Society. 126 (2), 496-504
BORRELLY, GPM., BLINDAUER, CA., SCHMID, R., BUTLER, CS., COOPER, CE., HARVEY, I., SADLER, PJ. and ROBINSON, NJ., (2004). A novel copper site in a cyanobacterial metallochaperone. Biochemical Journal. 378 (2), 293-297
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2004). The Radical and Redox Chemistry of Myoglobin and Hemoglobin: From In Vitro Studies to Human Pathology. Antioxidants & Redox Signaling. 6 (6), 954-966
(2004). Correction. Biophysical Journal. 87 (5), 3614-3616
Cooper, C., Isaac, S., Jones, MG., Crowther, T., Smith, BM. and Collin, HA., (2004). Morphological and biochemical response of carrots to Pythium violae, causative agent of Cavity Spot. Physiological and Molecular Plant Pathology. 64 (1), 27-35
Cooper, C., (2003). Competitive, Reversible, Physiological? Inhibition of Mitochondrial Cytochrome Oxidase by Nitric Oxide. IUBMB Life. 55 (10-11), 591-597
Cooper, CE., Davies, NA., Psychoulis, M., Canevari, L., Bates, TE., Dobbie, MS., Casley, CS. and Sharpe, MA., (2003). Nitric oxide and peroxynitrite cause irreversible increases in the Km for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1607 (1), 27-34
Cooper, CE. and Angus, C., (2003). Blood Volume Changes are Controlled Centrally Not Locally - A Near-Infrared Spectroscopy Study of One Legged Aerobic Exercise. Advances in Experimental Medicine and Biology. 530, 627-635
Svistunenko, DA., Reeder, BJ., Wilson, MT. and Cooper, CE., (2003). Radical Formation and Migration in Myoglobins. Progress in Reaction Kinetics and Mechanism. 28 (1), 105-118
Davies, NA., Cooper, CE., Stidwill, R. and Singer, M., (2003). Inhibition of Mitochondrial Respiration During Early Stage Sepsis. Advances in Experimental Medicine and Biology. 530, 725-736
McHugh, JP., Rodr铆guez-Qui帽ones, F., Abdul-Tehrani, H., Svistunenko, DA., Poole, RK., Cooper, CE. and Andrews, SC., (2003). Global Iron-dependent Gene Regulation in Escherichia coli. Journal of Biological Chemistry. 278 (32), 29478-29486
Murphy, MP., Echtay, KS., Blaikie, FH., Asin-Cayuela, J., Cochem茅, HM., Green, K., Buckingham, JA., Taylor, ER., Hurrell, F., Hughes, G., Miwa, S., Cooper, CE., Svistunenko, DA., Smith, RAJ. and Brand, MD., (2003). Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation. Journal of Biological Chemistry. 278 (49), 48534-48545
Sen, S., Ratnaraj, N., Davies, NA., Mookerjee, RP., Cooper, CE., Patsalos, PN., Williams, R. and Jalan, R., (2003). Treatment of Phenytoin Toxicity by the Molecular Adsorbents Recirculating System鈥(MARS). Epilepsia. 44 (2), 265-267
Cooper, CE., (2002). Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?. Trends in Biochemical Sciences. 27 (1), 33-39
Cooper, CE., Vollaard, NBJ., Choueiri, T. and Wilson, MT., (2002). Exercise, free radicals and oxidative stress. Biochemical Society Transactions. 30 (2), 280-285
Torres, J., Svistunenko, D., Karlsson, B., Cooper, CE. and Wilson, MT., (2002). Fast Reduction of a Copper Center in Laccase by Nitric Oxide and Formation of a Peroxide Intermediate. Journal of the American Chemical Society. 124 (6), 963-967
Cooper, CE., Patel, RP., Brookes, PS. and Darley-Usmar, VM., (2002). Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species. Trends in Biochemical Sciences. 27 (10), 489-492
Svistunenko, DA., Dunne, J., Fryer, M., Nicholls, P., Reeder, BJ., Wilson, MT., Bigotti, MG., Cutruzzol脿, F. and Cooper, CE., (2002). Comparative Study of Tyrosine Radicals in Hemoglobin and Myoglobins Treated with Hydrogen Peroxide. Biophysical Journal. 83 (5), 2845-2855
VOEVODSKAYA, NV., SEREZHENKOV, VA., COOPER, CE., KUBRINA, LN. and VANIN, AF., (2002). Exogenous ferrous iron is required for the nitric oxide-catalysed destruction of the iron鈥搒ulphur centre in adrenodoxin. Biochemical Journal. 368 (2), 633-639
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., Davies, NA., Cooper, CE. and Singer, M., (2002). Association between mitochondrial dysfunction and severity and outcome of septic shock. The Lancet. 360 (9328), 219-223
Kayyali, R., Porter, JB., Liu, ZD., Davies, NA., Nugent, JH., Cooper, CE. and Hider, RC., (2001). Structure-Function Investigation of the Interaction of 1- and 2-Substituted 3-Hydroxypyridin-4-ones with 5-Lipoxygenase and Ribonucleotide Reductase. Journal of Biological Chemistry. 276 (52), 48814-48822
ALDERTON, WK., COOPER, CE. and KNOWLES, RG., (2001). Nitric oxide synthases: structure, function and inhibition. Biochemical Journal. 357 (3), 593-593
Cooper, CE. and Davies, NA., (2000). Effects of nitric oxide and peroxynitrite on the cytochrome oxidase Km for oxygen: implications for mitochondrial pathology. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1459 (2-3), 390-396
Torres, J., Sharpe, MA., Rosquist, A., Cooper, CE. and Wilson, MT., (2000). Cytochrome c oxidase rapidly metabolises nitric oxide to nitrite. FEBS Letters. 475 (3), 263-266
Cooper, CE. and Wyatt, JS., (2000). NMR spectroscopy and imaging of the neonatal brain. Biochemical Society Transactions. 28 (2), 121-126
Svistunenko, DA., Sharpe, MA., Nicholls, P., Wilson, MT. and Cooper, CE., (2000). A New Method for Quantitation of Spin Concentration by EPR Spectroscopy: Application to Methemoglobin and Metmyoglobin. Journal of Magnetic Resonance. 142 (2), 266-275
SVISTUNENKO, DA., SHARPE, MA., NICHOLLS, P., BLENKINSOP, C., DAVIES, NA., DUNNE, J., WILSON, MT. and COOPER, CE., (2000). The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study. Biochemical Journal. 351 (3), 595-605
SVISTUNENKO, DA., SHARPE, MA., NICHOLLS, P., BLENKINSOP, C., DAVIES, NA., DUNNE, J., WILSON, MT. and COOPER, CE., (2000). The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study. Biochemical Journal. 351 (3), 595-595
Cooper, CE., (1999). Nitric oxide and iron proteins. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1411 (2-3), 290-309
Angus, C., Welford, D., Sellens, M., Thompson, S. and Cooper, CE., (1999). Estimation of Lactate Threshold by Near Infrared Spectroscopy. Advances in Experimental Medicine and Biology. 471, 283-288
Svistunenko, DA., Rob, A., Ball, A., Torres, J., Symons, MCR., Wilson, MT. and Cooper, CE., (1999). The electron paramagnetic resonance characterisation of a copper-containing extracellular peroxidase from Thermomonospora fusca BD25. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1434 (1), 74-85
Cooper, CE., (1999). Biochemistry of nitric oxide. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1411 (2-3), 215-216
Cooper, CE., (1999). In vivo measurements of mitochondrial function and cell death following hypoxic/ischaemic damage to the new-born brain. Biochemical Society Symposia. 66, 123-140
Cooper, CE., Cope, M., Springett, R., Amess, PN., Penrice, J., Tyszczuk, L., Punwani, S., Ordidge, R., Wyatt, J. and Delpy, DT., (1999). Use of Mitochondrial Inhibitors to Demonstrate That Cytochrome Oxidase Near-Infrared Spectroscopy Can Measure Mitochondrial Dysfunction Noninvasively in the Brain. Journal of Cerebral Blood Flow & Metabolism. 19 (1), 27-38
Heekeren, HR., Kohl, M., Obrig, H., Wenzel, R., von Pannwitz, W., Matcher, SJ., Dirnagl, U., Cooper, CE. and Villringer, A., (1999). Noninvasive Assessment of Changes in Cytochrome-c Oxidase Oxidation in Human Subjects during Visual Stimulation. Journal of Cerebral Blood Flow & Metabolism. 19 (6), 592-603
COOPER, CE., DELPY, DT. and NEMOTO, EM., (1998). The relationship of oxygen delivery to absolute haemoglobin oxygenation and mitochondrial cytochrome oxidase redox state in the adult brain: a near-infrared spectroscopy study. Biochemical Journal. 332 (3), 627-632
Dunne, J., Svistunenko, DA., Wilson, MT., Alayash, AI. and Cooper, CE., (1998). Reactions of cross-linked ferric haemoglobins with hydrogen peroxide. Biochemical Society Transactions. 26 (4), 9-15
Torres, J., Cooper, CE., Sharpe, M. and Wilson, MT., (1998). Reactivity of nitric oxide with cytochrome c oxidase: Interactions with the binuclear centre and mechanism of inhibition. Journal of Bioenergetics and Biomembranes. 30 (1), 63-69
Sharpe, MA. and Cooper, CE., (1998). Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase. Journal of Biological Chemistry. 273 (47), 30961-30972
SHARPE, MA. and COOPER, CE., (1998). Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite. Biochemical Journal. 332 (1), 9-19
Cooper, CE., Torres, J., Sharpe, MA., Wilson, MT. and Svistunenko, DA., (1998). Peroxynitrite Reacts with Methemoglobin to Generate Globin-Bound Free Radical Species. Advances in Experimental Medicine and Biology. 454, 195-202
Torres, J., Cooper, CE. and Wilson, MT., (1998). A Common Mechanism for the Interaction of Nitric Oxide with the Oxidized Binuclear Centre and Oxygen Intermediates of Cytochromec Oxidase. Journal of Biological Chemistry. 273 (15), 8756-8766
Firbank, M., Elwell, CE., Cooper, CE. and Delpy, DT., (1998). Experimental and theoretical comparison of NIR spectroscopy measurements of cerebral hemoglobin changes. Journal of Applied Physiology. 85 (5), 1915-1921
Quaresima, V., Springett, R., Cope, M., Wyatt, JT., Delpy, DT., Ferrari, M. and E. Cooper, C., (1998). Oxidation and reduction of cytochrome oxidase in the neonatal brain observed by in vivo near-infrared spectroscopy. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1366 (3), 291-300
Moore, KP., Holt, SG., Patel, RP., Svistunenko, DA., Zackert, W., Goodier, D., Reeder, BJ., Clozel, M., Anand, R., Cooper, CE., Morrow, JD., Wilson, MT., Darley-Usmar, V. and Roberts, LJ., (1998). A Causative Role for Redox Cycling of Myoglobin and Its Inhibition by Alkalinization in the Pathogenesis and Treatment of Rhabdomyolysis-induced Renal Failure. Journal of Biological Chemistry. 273 (48), 31731-31737
Nicholls, P., Sharpe, M., Torres, J., Wilson, MT. and Cooper, CE., (1998). 24 Nitric oxide as an effector and a substrate for cytochrome c oxidase. Biochemical Society Transactions. 26 (4), S323-S323
Dunne, J., Svistunenko, DA., Wilson, MT., Alayash, AI. and Cooper, CE., (1998). 20 Reactions of cross-linked ferric haemoglobins with hydrogen peroxide. Biochemical Society Transactions. 26 (4), S320-S320
Punwani, S., Ordidge, RJ., Cooper, CE., Amess, P. and Clemence, M., (1998). MRI measurements of cerebral deoxyhaemoglobin concentration [dHb]鈥攃orrelation with near infrared spectroscopy (NIRS). NMR in Biomedicine. 11 (6), 281-289
Roberts, IG., Fallon, P., Kirkham, FJ., Kirshbom, PM., Cooper, CE., Elliott, MJ. and Edwards, AD., (1998). Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy. The Journal of Thoracic and Cardiovascular Surgery. 115 (1), 94-102
(1997). Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?. FEBS Letters. 414 (2), 281-284
Wilson, MT., Torres, J., Cooper, CE. and Sharpe, MA., (1997). Interactions of cytochrome c oxidase with nitric oxide: reactions of the 鈥榯urnover鈥 intermediates. Biochemical Society Transactions. 25 (3), 905-909
Cooper, CE. and Porter, JB., (1997). Ribonucleotide reductase, lipoxygenase and the intracellular low-molecular-weight iron pool. Biochemical Society Transactions. 25 (1), 75-80
Cooper, CE. and Springett, R., (1997). Measurement of cytochrome oxidase and mitochondrial energetics by near鈥搃nfrared spectroscopy. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 352 (1354), 669-676
Cooper, CE., Cope, M., Quaresima, V., Ferrari, M., Nemoto, E., Springett, R., Matcher, S., Amess, P., Penrice, J., Tyszczuk, L., Wyatt, J. and Delpy, DT., (1997). Measurement of Cytochrome Oxidase Redox State by Near Infrared Spectroscopy. Advances in Experimental Medicine and Biology. 413, 63-73
DAVIES, NA., TRIKKAS, C. and COOPER, CE., (1997). Does carbon monoxide inhibit cytochrome oxidase in vivo?. Biochemical Society Transactions. 25 (3), 406S-406S
SHARPE, MA. and COOPER, CE., (1997). Nitric Oxide Reacts With Mitochondrial Cytochrome c. Biochemical Society Transactions. 25 (3), 407S-407S
SPRINGETT, RJ., PENRICE, JM., AMESS, PN., TYSZCZUK, L., DELPY, DT., WYATT, JS. and COOPER, CE., (1997). Non-Invasive measurements of mitochondrial damage during neonatal hypoxia-Ischaemia - a role for nitric oxide?. Biochemical Society Transactions. 25 (3), 398S-398S
Villringer, A., Heekeren, HR., Obrig, H., V. Pannwitz, W., Ramshorn, A., Kohl, M., Villringer, K. and Cooper, C., (1997). Cytochrome-oxidase oxidation in the occipital cortex during visual stimulation - A whole-spectrum near-infrared spectroscopy study. NeuroImage. 5 (4 PART II)
Wilson, MT., Torres, J., Sharpe, M. and Cooper, C., (1997). Reactions of Ntric Oxide with Cytochrome c Oxidase. Biochemical Society Transactions. 25 (3), 383S-383S
Penrice, J., Lorek, A., Cady, EB., Amess, PN., Wylezinska, M., Cooper, CE., D'Souza, P., Brown, GC., Kirkbride, V., Edwards, AD., Wyatt, JS. and Reynolds, EOR., (1997). Proton Magnetic Resonance Spectroscopy of the Brain during Acute Hypoxia-Ischemia and Delayed Cerebral Energy Failure in the Newborn Piglet. Pediatric Research. 41 (6), 795-802
Amess, PN., Penrice, J., Cady, EB., Lorek, A., Wylezinska, M., Cooper, CE., D'Souza, P., Tyszczuk, L., Thoresen, M., Edwards, AD., Wyatt, JS. and Reynolds, EOR., (1997). Mild Hypothermia after Severe Transient Hypoxia-Ischemia Reduces the Delayed Rise in Cerebral Lactate in the Newborn Piglet. Pediatric Research. 41 (6), 803-808
Punwani, S., Cooper, CE., Clemence, M., Penrice, J., Amess, P., Thornton, J. and Ordidge, RJ., (1997). Correlation between Absolute Deoxyhaemoglobin [dHb] Measured by Near Infrared Spectroscopy (NIRS) and Absolute R2鈥 as Determined by Magnetic Resonance Imaging (MRI). Advances in Experimental Medicine and Biology. 413, 129-137
Yue, X., Mehmet, H., Penrice, J., Cooper, C., Cady, E., Wyatt, JS., Reynolds, EOR., Edwards, AD. and Squier, MV., (1997). Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia鈥搃schaemia. Neuropathology and Applied Neurobiology. 23 (1), 16-25
COOPER, CE., PEZESHK, A., TORRES, J., WILSON, M. and SYMONS, MRC., (1996). A new EPR signal from cytochrome oxidase - evidence for conformational flexibility at the CuB site?. Biochemical Society Transactions. 24 (3), 465S-465S
COOPER, CE., PANAGIOTOPOULUOROGER, JSA. and PENRICE, J., (1996). Near infrared spectroscopy of nitrosyl haemoglobin - relevance to in vivo detection of nitric oxide. Biochemical Society Transactions. 24 (3), 448S-448S
Cooper, CE., Lynagh, GR., Hoyes, KP., Hider, RC., Cammack, R. and Porter, JB., (1996). The Relationship of Intracellular Iron Chelation to the Inhibition and Regeneration of Human Ribonucleotide Reductase. Journal of Biological Chemistry. 271 (34), 20291-20299
Cooper, CE., Elwell, CE., Meek, JH., Matcher, SJ., Wyatt, JS., Cope, M. and Delpy, DT., (1996). The Noninvasive Measurement of Absolute Cerebral Deoxyhemoglobin Concentration and Mean Optical Path Length in the Neonatal Brain by Second Derivative Near Infrared Spectroscopy. Pediatric Research. 39 (1), 32-38
Abeysinghe, RD., Roberts, PJ., Cooper, CE., MacLean, KH., Hider, RC. and Porter, JB., (1996). The Environment of the Lipoxygenase Iron Binding Site Explored with Novel Hydroxypyridinone Iron Chelators. Journal of Biological Chemistry. 271 (14), 7965-7972
Shergill, JK., Cammack, R., Cooper, CE., Cooper, JM., Mann, VM. and Schapira, AHV., (1996). Detection of Nitrosyl Complexes in Human Substantia Nigra, in Relation to Parkinson's Disease. Biochemical and Biophysical Research Communications. 228 (2), 298-305
Cooper, CE. and Brown, GC., (1995). The Interactions between Nitric Oxide and Brain Nerve Terminals as Studied by Electron Paramagnetic Resonance. Biochemical and Biophysical Research Communications. 212 (2), 404-412
Thoresen, M., Penrice, J., Lorek, A., Cady, EB., Wylezinska, M., Kirkbride, V., Cooper, CE., Brown, GC., Edwards, AD., Wyatt, JS. and Reynolds, EOR., (1995). Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet. Pediatric Research. 37 (5), 667-670
Edwards, AD., Yue, X., Squier, MV., Thoresen, M., Cady, EB., Penrice, J., Cooper, CE., Wyatt, JS., Reynolds, EOR. and Mehmet, H., (1995). Specific Inhibition of Apoptosis after Cerebral Hypoxia-Ischemia by Moderate Post-Insult Hypothermia. Biochemical and Biophysical Research Communications. 217 (3), 1193-1199
Matcher, SJ., Elwell, CE., Cooper, CE., Cope, M. and Delpy, DT., (1995). Performance Comparison of Several Published Tissue Near-Infrared Spectroscopy Algorithms. Analytical Biochemistry. 227 (1), 54-68
Moody, AJ., Cooper, CE., Gennis, RB., Rumbley, JN. and Rich, PR., (1995). Interconversion of Fast and Slow Forms of Cytochrome bo from Escherichia coli. Biochemistry. 34 (20), 6838-6846
Cooper, CE., Green, ESR., Rice-evans, CA., Davies, MJ. and Wriggleswort, JM., (1994). A Hydrogen-Donating Monohydroxamate Scavenges Ferryl Myoglobin Radicals. Free Radical Research. 20 (4), 219-227
Mehmet, H., Yue, X., Squier, MV., Lorek, A., Cady, E., Penrice, J., Sarraf, C., Wylezinska, M., Kirkbride, V., Cooper, C., Brown, GC., Wyatt, JS., Reynolds, EOR. and Edwards, AD., (1994). Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult. Neuroscience Letters. 181 (1-2), 121-125
Cady, EB., Lorek, A., Penrice, J., Edwards, AD., Brown, G., Owen-Reece, H., Kirkbride, V., Cooper, CE., Wyatt, JS. and Reynolds, EOR., (1994). Large increases in1H metaboliteT 2's after cerebral hypoxia-ischemia correlate with ATP depletion. Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2 (3), 441-444
Brown, GC. and Cooper, CE., (1994). The analysis of rate limitation within enzymes: relations between flux control coefficients of rate constants and unidirectional rates, rate constants and thermodynamic parameters of single isolated enzymes. Biochemical Journal. 300 (1), 159-164
Matcher, SJ. and Cooper, CE., (1994). Absolute quantification of deoxyhaemoglobin concentration in tissue near infrared spectroscopy. Physics in Medicine and Biology. 39 (8), 1295-1312
Tan, HM., Joannou, CL., Cooper, CE., Butler, CS., Cammack, R. and Mason, JR., (1994). The effect of ferredoxin(BED) overexpression on benzene dioxygenase activity in Pseudomonas putida ML2. Journal of Bacteriology. 176 (9), 2507-2512
Cady, EB., Lorek, A., Penrice, J., Wylezinska, M., Cooper, CE., Brown, GC., Owen-Reece, H., Kirkbride, V., Wyatt, JS., Osmund, E. and Reynolds, R., (1994). Brain-metabolite transverse relaxation times in magnetic resonance spectroscopy increase as adenosine triphosphate depletes during secondary energy failure following acute hypoxia-ischaemia in the newborn piglet. Neuroscience Letters. 182 (2), 201-204
Cady, EB., Lorek, A., Takei, Y., Wyatt, JS., Penrice, JM., Edwards, AD., Peebles, D., Wylezinska, M., Owen-Reece, H., Kirkbride, V., Cooper, CE., Aldridge, RF., Roth, SC., Brown, G., Delpy, DT. and Reynolds, EOR., (1994). Severity of delayed (鈥渟econdary鈥) cerebral energy failure after acute hypoxia-ischemia is related to the time integral of acute ATP depletion. Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2 (3), 437-439
Brown, GC. and Cooper, CE., (1994). Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Letters. 356 (2-3), 295-298
Lorek, A., Takei, Y., Cady, EB., Wyatt, JS., Penrice, J., Edwards, AD., Peebles, D., Wylezinska, M., Owen-Reece, H., Kirkbride, V., Cooper, CE., Aldridge, RF., Roth, SC., Brown, G., Delpy, DT. and Reynolds, EOR., (1994). Delayed (鈥淪econdary鈥) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy. Pediatric Research. 36 (6), 699-706
COOPER, CE., (1994). Ferryl iron and protein free radicals. 28 (C), 67-111
Sharpe, MA., Cooper, CE. and Wrigglesworth, JM., (1994). Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids. The Journal of Membrane Biology. 141 (1), 21-28
Brown, GC. and Cooper, CE., (1993). Control analysis applied to single enzymes: can an isolated enzyme have a unique rate-limiting step?. Biochemical Journal. 294 (1), 87-94
Cammack, R. and Cooper, CE., (1993). [12] Electron paramagnetic resonance spectroscopy of iron complexes and iron-containing proteins. Methods in Enzymology. 227 (C), 353-384
Cooper, CE., Markus, M., Seetulsingh, SP. and Wrigglesworth, JM., (1993). Kinetics of inhibition of purified and mitochondrial cytochrome c oxidase by psychosine (尾-galactosylsphingosine). Biochemical Journal. 290 (1), 139-144
Cooper, CE., Markus, M., Seetulsingh, SP. and Wrigglesworth, JM., (1993). Kinetcs of inhibition of purified and mitochondrial cytochrome c oxidase by psychosine (尾-galactosylsphingosine). Biochemical Journal. 290 (1), 139-144
Roberts, I., Fallon, P., Kirkham, F., Lloyd-Thomas, A., Cooper, C., Maynard, R., Elliot, M. and Edwards, AD., (1993). Estimation of cerebral blood flow with near infrared spectroscopy and indocyanine green. The Lancet. 342 (8884), 1425-1425
Cooper, CE., J眉nemann, S., Ioannidis, N. and Wrigglesworth, JM., (1993). Slow (鈥榬esting鈥) forms of mitochondrial cytochrome c oxidase consist of two kinetically distinct conformations of the binuclear CuBa3 centre 鈥 relevance to the mechanism of proton translocation. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1144 (2), 149-160
Dorey, C., Cooper, C., Dickson, DPE., Gibson, JF., Simpson, RJ. and Peters, TJ., (1993). Iron speciation at physiological pH in media containing ascorbate and oxygen. British Journal of Nutrition. 70 (1), 157-169
Rice-Evans, C., Green, E., Paganga, G., Cooper, C. and Wrigglesworth, J., (1993). Oxidised low density lipoproteins induce iron release from activated myoglobin. FEBS Letters. 326 (1-3), 177-182
Simpson, RJ., Cooper, CE., Raja, KB., Halliwell, B., Evans, PJ., Arouma, OI., Singh, S. and Konijn, AM., (1992). Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice. Biochimica et Biophysica Acta (BBA) - General Subjects. 1156 (1), 19-26
Ioannidis, N., Cooper, CE. and Poole, RK., (1992). Spectroscopic studies on an oxygen-binding haemoglobin-like flavohaemoprotein from Escherichia coli. Biochemical Journal. 288 (2), 649-655
Cooper, CE. and Odell, E., (1992). Interaction of human myeloperoxidase with nitrite. FEBS Letters. 314 (1), 58-60
Cooper, CE. and Salerno, JC., (1992). Characterization of a novel g' = 2.95 EPR signal from the binuclear center of mitochondrial cytochrome c oxidase.. Journal of Biological Chemistry. 267 (1), 280-285
Cooper, CE., Nicholls, P. and Freedman, JA., (1991). Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits. Biochemistry and Cell Biology. 69 (9), 586-607
Moody, AJ., Cooper, CE. and Rich, PR., (1991). Characterisation of 鈥榝ast鈥 and 鈥榮low鈥 forms of bovine heart cytochrome-c oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1059 (2), 189-207
Cooper, CE., (1990). The steady-state kinetics of cytochrome c oxidation by cytochrome oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1017 (3), 187-203
Wrigglesworth, JM., Cooper, CE., Sharpe, MA. and Nicholls, P., (1990). The proteoliposomal steady state. Effect of size, capacitance and membrane permeability on cytochrome-oxidase-induced ion gradients. Biochemical Journal. 270 (1), 109-118
Cooper, CE. and Nicholls, P., (1990). Structure and vectorial properties of proteoliposomes containing cytochrome oxidase in the submitochondrial orientation. Biochemistry. 29 (16), 3865-3871
Cooper, CE., Bruce, D. and Nicholls, P., (1990). Use of Oxonol V as a probe of membrane potential in proteoliposomes containing cytochrome oxidase in the submitochondrial orientation. Biochemistry. 29 (16), 3859-3865
Cooper, CE., Wrigglesworth, JM. and Nicholls, P., (1990). The mechanism of potassium movement across the liposomal membrane. Biochemical and Biophysical Research Communications. 173 (3), 1008-1012
Nicholls, P., Cooper, CE. and Wrigglesworth, JM., (1990). Control of proteoliposomal cytochrome c oxidase: the overall reaction. Biochemistry and Cell Biology. 68 (9), 1128-1134
Nicholls, P. and Cooper, CE., (1989). Modulation of cytochrome oxidase kinetics by indirect antibody action. FEBS Letters. 250 (2), 453-458
Nicholls, P., Cooper, CE., Leece, B., Freedman, JA. and Chan, SH., (1988). Antibodies as probes of cytochrome oxidase structure and function.. Progress in clinical and biological research. 274, 637-651
Nicholls, P., Cooper, CE., Freedman, JA. and Leece, BD., (1988). Effects of antibodies to intact cytochrome-c oxidase and its subunit V on the enzymatic activity. Biochemistry and Cell Biology. 66 (11), 1218-1225
Freedman, JA., Leece, B., Cooper, CE., Nicholls, P. and Chan, SHP., (1988). Effects of subunit V antibodies on the topology of the subunit and the activity of beef heart cytochrome-c oxidase. Biochemistry and Cell Biology. 66 (11), 1210-1217
Cooper, CE. and Nicholls, P., (1987). Activity of proteoliposomes containing cytochrome oxidase in the submitochondrial orientation. FEBS Letters. 223 (1), 155-160
Books (2)
Cooper, CE., (2016). . Oxford University Press. 9780199581450
Cooper, C., (2012). . Oxford University Press. 0199581460. 9780199581467
Book chapters (3)
Jones, B. and Cooper, CE., (2018). Near Infrared Spectroscopy (NIRS) observation of vastus lateralis (muscle) and prefrontal cortex (brain) tissue oxygenation during synchronised swimming routines in elite athletes. In: Oxygen Transport to Tissue XL. Editors: Thews, O., LaManna, J. and Harrison, D., . Springer. 111- 117. 978-3-319-91285-1
Silkstone, GGA., Simons, M., Rajagopal, BS., Shaik, T., Reeder, BJ. and Cooper, CE., (2018). Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes.. In: Oxygen Transport to Tissue XL. Editors: Thews, O., LaManna, J. and Harrison, D., . Springer. 221- 225. 978-3-319-91285-1
Silkstone, RS., Silkstone, G., Baath, JA., Rajagopal, BS., Nicholls, P., Reeder, BJ., Ronda, L., Bulow, L. and Cooper, CE., (2016). The ?Lys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute. In: Oxygen Transport to Tissue XXXVII. Editors: Elwell, CE., Leung, TS. and Harrison, DK., . Springer. 455- 460
Conferences (46)
Cooper, CE., Bird, M., Sheng, X., Simons, M., Ronda, L., Mozzarelli, A. and Reeder, BJ., (2022).
Moroz, T., Hapuarachchi, T., Bainbridge, A., Price, D., Cady, E., Baer, E., Broad, K., Ezzati, M., Thomas, D., Golay, X., Robertson, NJ., Cooper, CE. and Tachtsidis, I., (2013).
Jones, B., Hesford, CM. and Cooper, CE., (2013). The use of portable NIRS to measure muscle oxygenation and haemodynamics during a repeated sprint running test
Rong, Z. and Cooper, CE., (2013). Modeling hemoglobin nitrite reductase activity as a mechanism of hypoxic vasodilation?
Moroz, T., Hapuarachchi, T., Bainbridge, A., Price, D., Cady, E., Baer, E., Tachtsidis, I., Broad, K., Ezzati, M., Robertson, NJ., Thomas, D., Golay, X. and Cooper, CE., (2013). Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating brain energetics
Hesford, CM., Laing, S. and Cooper, CE., (2013). Using portable NIRS to compare arm and leg muscle oxygenation during roller skiing in biathletes: A case study
Rong, Z., Banaji, M., Moroz, T. and Cooper, CE., (2013). Can mitochondrial cytochrome oxidase mediate hypoxic vasodilation via nitric oxide metabolism?
Hesford, C., Cardinale, M., Laing, S. and Cooper, CE., (2013). NIRS measurements with elite speed skaters: Comparison between the ice rink and the laboratory
Nicholls, P., Mason, MG. and Cooper, CE., (2012). Cytochrome c oxidase heme and Cu centres: Redox and spectral interactions
Moroz, T., Banaji, M., Tisdall, M., Cooper, CE., Elwell, CE. and Tachtsidis, I., (2012). Development of a Model to Aid NIRS Data Interpretation: Results from a Hypercapnia Study in Healthy Adults
Ghosh, A., Tachtsidis, I., Kolyva, C., Cooper, CE., Smith, M. and Elwell, CE., (2012). Use of a Hybrid Optical Spectrometer for the Measurement of Changes in Oxidized Cytochrome c Oxidase Concentration and Tissue Scattering During Functional Activation
Gao, L., ElwellElwell, CE., Kohl-Bareis, M., Gramer, M., Cooper, CE., Leung, TS. and Tachtsidis, I., (2011).
Nicholls, P., Mason, MG. and Cooper, CE., (2010). Cytochrome c Oxidase CuA and Heme A: Redox Equilibrium and Interactions
Hesford, C., Cooper, CE. and Cardinale, M., (2010).
Tachtsidis, I., Gao, L., Leung, TS., Kohl-Bareis, M., Cooper, CE. and Elwell, CE., (2010). A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Spectrometer and Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum
Leung, TS., Wittekind, A., Binzoni, T., Beneke, R., Cooper, CE. and Elwell, CE., (2010).
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2009).
Tachtsidis, I., Tisdall, MM., Leung, TS., Pritchard, C., Cooper, CE., Smith, M. and Elwell, CE., (2009).
Mason, MG., Nichols, P. and Cooper, CE., (2008).
Nicholls, P. and Cooper, CE., (2008).
Tachtsidis, I., Leung, TS., Tahir, B., Elwell, CE., Kohl-Bareis, M., Gramer, M. and Cooper, CE., (2008). A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum: Results from Studies in Dynamic Phantoms
Leung, TS., Tachtsidis, I., Elwell, CE., Tisdall, M., Pritchard, C., Smith, M. and Cooper, C., (2008).
Reeder, BJ., Nilson, M., Bulow, L., Cooper, CE. and Wilson, MT., (2007). Modulating electron transfer pathways in hemoglobin
Myers, DE., Cooper, CE., Beilman, GJ., Mowlem, JD., Anderson, LD., Seifert, RP. and Ortner, JP., (2006). A Wide Gap Second Derivative NIR Spectroscopic Method for Measuring Tissue Hemoglobin Oxygen Saturation
Vollaard, NB., Shearman, JP. and Cooper, CE., (2004). The oxidative stress response to exercise is unchanged after tapering, but antioxidant defenses are improved
Tachtsidis, L., Cooper, CE., McGown, AD., Makker, H., Delpy, DT. and Elwell, CE., (2004). Changes in cerebral total haemoglobin volume and cytochrome oxidase redox state during deep apnoeas in patients with obstructive sleep apnoea
Nicholls, P., Cooper, CE. and Reynolds, CV., (2001). Tyrosinyl nitration by peroxidase & other hemoproteins
Davies, NA., Hodges, SJ., Mookerjee, RP., Sen, S., Cooper, CE. and Jalan, R., (2001). Evidence of significant oxidative stress and free radical activity in alcoholic hepatitis
Dunne, J., Svistunenko, DA., Alayash, AI., Wilson, MT. and Cooper, CE., (1999). Increased free radical formation by hemoglobin based oxygen carriers.
Davies, NA., Wyatt, JS. and Cooper, CE., (1999). Use of Elecron Paramagnetic Resonance spectroscopy to determine nitric oxide overproduction during hypoxic-ischaemic damage to the neonatal brain.
Dunne, J., Svistunenko, DA., Alayash, AI., Wilson, MT. and Cooper, CE., (1999). Reactions of Cross-Linked Methaemoglobins with Hydrogen Peroxide
A. Svistunenko, D., A. Davies, N., T. Wilson, M., P. Stidwill, R., Singer, M. and E. Cooper, C., (1997). Free radical in blood: a measure of haemoglobin autoxidation in vivo?鈥娾
Cooper, C., Sharpe, M., Elwell, C., Springett, R., Penrice, J., Tyszczuk, L., Amess, P., Wyatt, J., Quaresima, V. and Delpy, D., (1997). The Cytochrome Oxidase Redox State in Vivo
TORRES, J., COOPER, CC. and WILSON, MT., (1996). Possible interaction of nitric oxide with the ferryl intermediate of cytochrome c oxidase
Sharpe, M., Perin, I., Nicholls, P. and Cooper, C., (1996). Free fatty acids as modulators of cytochrome c oxidase activity
Cooper, CE., Ioannidis, N., D'mello, R. and Poole, RK., (1994). Haem, flavin and oxygen interactions in Hmp, a flavohaemoglobin from Escherichia coli
Elwell, CE., Cope, M., Kirkby, D., Owen-Reece, H., Cooper, CE., Reynolds, EOR. and Delpy, DT., (1994). An Automated System for the Measurement of the Response of Cerebral Blood Volume and Cerebral Blood Flow to Changes in Arterial Carbon Dioxide Tension Using Near Infrared Spectroscopy
Cooper, CE., Matcher, SJ., Wyatt, JS., Cope, M., Brown, GC., Nemoto, EM. and Delpy, DT., (1994). Near-infrared spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics
(1994). Relation between cerebral nucleotide triphosphate depletion due to acute hypoxiaischaemia, and secondary energy failure in the newborn piglet
COOPER, CE., IOANNIDIS, N., DMELLO, R. and POOLE, RK., (1994). HEME, FLAVIN AND OXYGEN INTERACTIONS IN HMP, A FLAVOHAEMOGLOBIN FROM ESCHERICHIA-COLI
Wrigglesworth, JM., Sharpe, MA. and Cooper, CE., (1993). Regulation of electron flux through cytochrome c oxidase: pH, 螖pH and fatty acids
Green, ESR., Cooper, CE., Davies, MJ. and Rice-Evans, C., (1993). Antioxidant drugs and the inhibition of low-density lipoprotein oxidation
COOPER, CE. and ODELL, E., (1992). EPR differences between human myeloperoxidase isoenzymes
GREEN, ES., COOPER, C., WRIGGLESWORTH, J. and RICE-EVANS, C., (1992). A NOVEL HYDROGEN-DONATING DRUG SUPPRESSES HAEM DAMAGE FROM MYOGLOBIN MEDIATED BY OXIDISED LOW DENSITY LIPOPROTEINS
Sharpe, MA., Cooper, CE. and Wrigglesworth, JM., (1991). The Effect of Membrane Potential on the Protonophoric Action of Oleic Acid
COOPER, CE., MOODY, AJ., RICH, PR., WRIGGLESWORTH, JM. and IOANNIDIS, N., (1991). The cytochrome oxidase g'=12 EPR signal
Grants and funding
2013
Creating an Effective and Non Toxic Blood Substitute
Biotechnology & Biology Science Res.Council
Engineering a new generation of blood substitutes
Medical Research Council
2012
Quantification of the Effect of Adipose Tissue Thickness
Artinis Medical Systems B.V.
Blood Substitutes Project
Iceni Seedcorn Fund
Creating an effective and non toxic blood substitute
Biotechnology & Biology Science Res.Council
2010
Novel Methods to measure brain and oxygen metabolism
The Royal Society
Gas signalling and biological energy
Leverhulme Trust
Heme blockers: Reducing the toxicity of extracellular
Biotechnology & Biology Science Res.Council
Integrating monitoring & modelling for real-time tracking
Wellcome Trust
2009
Non-Invasive Multi Modal Cerebral Monitoring
Medical Research Council
Haem Therapeutics Pathfinder
Iceni Seedcorn Fund
2008
Artificial Blood
Biotechnology & Biology Science Res.Council
ISIS - Free Radical Chemistry of Haemoglobin
Biotechnology & Biology Science Res.Council
The Magic Of Blood: Shining Light On Chemistry, Physics & Bi
Engineering & Physical Sciences Res.Council
OMI Studentship - Catherine Hesford
Olympic Medical Institute