Dr Metodi Metodiev
-
Email
mmetod@essex.ac.uk -
Location
3SW.4.20, Colchester Campus
-
Academic support hours
Friday 14:00-16:00
Profile
Biography
Employment: Senior Lecturer, School of Biological Sciences, 糖心Vlog, Oct 2011 - present Lecturer, School of Biological Sciences, 糖心Vlog, Nov 2004 - Oct 2011 Research Assistant Professor, Laboratory for Molecular Biology, Biological Sciences, University of Illinois at Chicago, Sep 1999 - Sep 2004 Education: PhD in Biological Sciences, Bulgarian Academy of Sciences, Bulgaria, 1990 - 1994 MSc in Biology, Sofia University St Kliment Ohridsky, Bulgaria, 1984 - 1989 Post-graduate certificate "C programming for Bioinformatics", University of Manchester, United Kingdom, Oct 2003 - Feb 2004 Research: Translational research; enabling personalized cancer therapy by proteogenomics: we combine computational data analysis with proteomics experiments conducted in the lab to identify and validate new diagnostic biomarkers and drug target candidates. Basic research; molecular mechanisms of signal transduction in the context of cancer: Since 2014 we apply the revolutionary CRISPR/Cas9 technique to edit candidate genes in the genome of human cell lines and study the effects of mutations found in large NGS datasets. One particular focus is the candidate tumour suppressor SCRIB. We have incorporated the CRISPR/Cas9 technique in our final-year and MSc research projects. Research students: Mrs Makarim Al-Zubaidi Ms Nosheen Faiz (co-supervisor with Professor B. Lausen) Former PhD students: Dr Nikos Parisis Dr Fahri Hejazi Dr Esther Adewuyi Dr Samson Adoki
Qualifications
-
PhD in Biological Sciences Bulgarian Academy of Sciences, (1994)
-
MSc in Biology Sofia University St Kliment Ohridsky, (1989)
-
Post-graduate certificate "C programming for Bioinformatics" University of Manchester, (2004)
Appointments
Other academic
-
Senior Lecturer, School of Biological Sciences, 糖心Vlog (1/10/2011 - present)
-
Lecturer, School of Biological Sciences, 糖心Vlog (1/11/2004 - 1/10/2011)
Research and professional activities
Research interests
cell signalling
biological mass spectrometry
cancer biology
Current research
Proteogenomics of cancer
My research and interests are in the field of cell and molecular biology and genomics/proteomics with special emphasize on cancer. We use quantitative mass spectrometry, molecular genetics, and computational approaches and statistics to study how aberrant protein expression, protein interactions and phosphorylation affect the tumour phenotype. The long term aim is to contribute to the development of novel diagnostics and therapies for cancer.
Teaching and supervision
Current teaching responsibilities
-
Transferable Skills in Life Sciences (BS143)
-
Genome Science (BS222)
-
Molecular Basis of Cancer (BS349)
-
Research Project in Biomedical Science (BS831)
-
Molecular Mechanisms of Disease (BS938)
-
Protein Technologies and Proteomics (BS983)
-
Medical Genetics (BS220)
Previous supervision
Degree subject: Statistics
Degree type: Doctor of Philosophy
Awarded date: 8/7/2021
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 8/1/2020
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 30/9/2016
Publications
Publications (1)
Metodiev, M., (2024). MGVB: a new proteomics toolset for fast and efficient data analysis
Journal articles (47)
Vasileva-Slaveva, M., Kostova-Lefterova, D., Simeonov, F., Yordanov, A. and Metodiev, M., (2025). Breast cancer in Bulgaria prior implementation of a national breast cancer screening program and certified breast centers. Journal of Cancer Policy. 43, 100531-100531
Metodiev, MV., (2025). MGVB: a New Proteomics Toolset for Fast and Efficient Data Analysis. Journal of Proteome Research. 24 (4), 2181-2187
Tsoneva, E., Dimitrova, P., Metodiev, M., Shivarov, V., Vasileva-Slaveva, M., Yordanov, A. and Kostov, S., (2024). Utility of聽expression of聽4-hydroxynonenal tested by immunohistochemistry for cervical cancer. Menopausal Review. 23 (1), 6-13
Vasileva-Slaveva, M., Yordanov, A., Metodieva, G. and Metodiev, MV., (2024). Exploring Protein Post-Translational Modifications of Breast Cancer Cells Using a Novel Combinatorial Search Algorithm. International Journal of Molecular Sciences. 25 (18), 9902-9902
Tsoneva, E., Dimitrova, PD., Metodiev, M., Shivarov, V., Vasileva-Slaveva, M. and Yordanov, A., (2023). The effects of ROMO1 on cervical cancer progression. Pathology - Research and Practice. 248, 154561-154561
McKew, BA., Johnson, R., Clothier, L., Skeels, K., Ross, MS., Metodiev, M., Frenzel, M., Gieg, LM., Martin, JW., Hough, MA. and Whitby, C., (2021). . MicrobiologyOpen. 10 (4), e1196-
Gregson, BH., Metodieva, G., Metodiev, MV., Golyshin, PN. and McKew, BA., (2020). . Environmental Microbiology. 22 (5), 1870-1883
Gregson, BH., Metodieva, G., Metodiev, MV. and McKew, BA., (2019). . Environmental Microbiology. 21 (7), 2347-2359
Waszczak, N., DeFlorio, R., Ismael, A., Cheng, N., Stone, DE. and Metodiev, MV., (2019). Quantitative proteomics reveals a G伪/MAPK signaling hub that controls pheromone-induced cellular polarization in yeast. Journal of Proteomics. 207, 103467-103467
Gregson, BH., Metodieva, G., Metodiev, MV., Golyshin, PN. and McKew, BA., (2018). . Frontiers in Microbiology. 9, 3130-
Welbourn, EM., Wilson, MT., Yusof, A., Metodiev, MV. and Cooper, CE., (2017). . Free Radical Biology and Medicine. 103, 95-106
Todorova, K., Metodiev, MV., Metodieva, G., Mincheff, M., Fern谩ndez, N. and Hayrabedyan, S., (2017). . Hormones and Cancer. 8 (1), 28-48
Harrod, A., Fulton, J., Nguyen, VTM., Periyasamy, M., Ramos-Garcia, L., Lai, C-F., Metodieva, G., de Giorgio, A., Williams, RL., Santos, DB., Gomez, PJ., Lin, M-L., Metodiev, MV., Stebbing, J., Castellano, L., Magnani, L., Coombes, RC., Buluwela, L. and Ali, S., (2017). . Oncogene. 36 (16), 2286-2296
Mitchell, MC., Metodieva, G., Metodiev, M., Griffiths, H. and Meyer, MT., (2017). . Journal of Experimental Botany. 68 (14), 3891-3902
Hayrabedyan, S., Todorova, K., Jabeen, A., Metodieva, G., Toshkov, S., Metodiev, M., Mincheff, M. and Fern锟絥dez, N., (2016). . Scientific Reports. 6 (18896), 18896-
Metodieva, G., Adoki, S., Lausen, B. and Metodiev, MV., (2016). . EBioMedicine. 8, 150-158
Ismael, A., Tian, W., Waszczak, N., Wang, X., Cao, Y., Suchkov, D., Bar, E., Metodiev, M., Liang, J., Arkowitz, RA. and Stone, DE., (2016). . Science Signaling. 9 (423), ra38-
Croner, R., Sevim, M., Metodiev, M., Jo, P., Ghadimi, M., Schellerer, V., Brunner, M., Geppert, C., Rau, T., St眉rzl, M., Naschberger, E., Matzel, K., Hohenberger, W., Lottspeich, F. and Kellermann, J., (2016). . International Journal of Molecular Sciences. 17 (2), 209-209
Todorova, K., Metodiev, MV., Metodieva, G., Zasheva, D., Mincheff, M. and Hayrabedyan, S., (2016). . Molecular Carcinogenesis. 55 (2), 131-147
McKew, BA., Metodieva, G., Raines, CA., Metodiev, MV. and Geider, RJ., (2015). . Environmental Microbiology. 17 (10), 4050-4062
Mock, T., Daines, SJ., Geider, RJ., Collins, S., Metodiev, M., Millar, AJ., Moulton, V. and Lenton, TM., (2015). . Global Change Biology. 22 (1), 61-75
Mahmoud, O., Harrison, A., Perperoglou, A., Gul, A., Khan, Z., Metodiev, MV. and Lausen, B., (2014). . BMC Bioinformatics. 15 (1), 274-
Croner, RS., St眉rzl, M., Rau, TT., Metodieva, G., Geppert, CI., Naschberger, E., Lausen, B. and Metodiev, MV., (2014). . International Journal of Cancer. 135 (12), 2878-2886
Mckew, BA., Lefebvre, SC., Achterberg, EP., Metodieva, G., Raines, CA., Metodiev, MV. and Geider, RJ., (2013). . New Phytologist. 200 (1), 61-73
McKew, BA., Davey, P., Finch, SJ., Hopkins, J., Lefebvre, SC., Metodiev, MV., Oxborough, K., Raines, CA., Lawson, T. and Geider, RJ., (2013). . New Phytologist. 200 (1), 74-85
DeFlorio, R., Brett, M-E., Waszczak, N., Apollinari, E., Metodiev, MV., Dubrovskyi, O., Eddington, D., Arkowitz, RA. and Stone, DE., (2013). . Journal of Cell Science. 126 (14), 2997-3009
Metodieva, G., Nogueira-de-Souza, NC., Greenwood, C., Al-Janabi, K., Leng, L., Bucala, R. and Metodiev, MV., (2013). . Neoplasia. 15 (6), 660-IN21
Parisis, N., Metodieva, G. and Metodiev, MV., (2013). . Journal of Proteomics. 80, 91-106
DeFlorio, R., Brett, M., Waszczak, N., Apollinari, E., Metodiev, M., Dubrovskyi, O., Eddington, D., Arkowitz, RA. and Stone, DE., (2013). Phosphorylation of G? is crucial for efficient chemotropism in yeast. Journal of Cell Science. 126 (14), 2997-3009
Karakikes, I., Morrison, IEG., O'Toole, P., Metodieva, G., Navarrete, CV., Gomez, J., Miranda鈥怱ayago, JM., Cherry, RJ., Metodiev, M. and Fernandez, N., (2012). . The FASEB Journal. 26 (12), 4886-4896
Greenwood, C., Metodieva, G., Al-Janabi, K., Lausen, B., Alldridge, L., Leng, L., Bucala, R., Fernandez, N. and Metodiev, MV., (2012). . Journal of Proteomics. 75 (10), 3031-3040
Howard, TP., Fryer, MJ., Singh, P., Metodiev, M., Lytovchenko, A., Obata, T., Fernie, AR., Kruger, NJ., Quick, WP., Lloyd, JC. and Raines, CA., (2011). . Plant Physiology. 157 (2), 620-631
Metodiev, MV., (2011). . Methods in molecular biology (Clifton, N.J.). 790, 99-113
Metodieva, G., Greenwood, C., Alldridge, L., Sauven, P. and Metodiev, M., (2009). . PROTEOMICS 鈥� Clinical Applications. 3 (1), 78-82
Zaichick, SV., Metodiev, MV., Nelson, SA., Durbrovskyi, O., Draper, E., Cooper, JA. and Stone, DE., (2009). . Molecular Biology of the Cell. 20 (12), 2820-2830
Howard, TP., Metodiev, M., Lloyd, JC. and Raines, CA., (2008). . Proceedings of the National Academy of Sciences. 105 (10), 4056-4061
Krey, G., Frank, P., Shaikly, V., Barrientos, G., Cordo-Russo, R., Ringel, F., Moschansky, P., Chernukhin, IV., Metodiev, M., Fern谩ndez, N., Klapp, BF., Arck, PC. and Blois, SM., (2008). . Journal of Molecular Medicine. 86 (9), 999-1011
Alldridge, L., Metodieva, G., Greenwood, C., Al-Janabi, K., Thwaites, L., Sauven, P. and Metodiev, M., (2008). . Journal of Proteome Research. 7 (4), 1458-1469
Metodiev, M. and Alldridge, L., (2008). . PROTEOMICS 鈥� Clinical Applications. 2 (2), 181-194
D'Arcy, V., Abdullaev, ZK., Pore, N., Docquier, F., Torrano, V., Chernukhin, I., Smart, M., Farrar, D., Metodiev, M., Fernandez, N., Richard, C., Delgado, MD., Lobanenkov, V. and Klenova, E., (2006). The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis. Clinical Cancer Research. 12 (20), 5978-5986
Matheos, D., Metodiev, M., Muller, E., Stone, D. and Rose, MD., (2004). . The Journal of Cell Biology. 165 (1), 99-109
Metodiev, MV., Matheos, D., Rose, MD. and Stone, DE., (2002). . Science. 296 (5572), 1483-1486
Metodiev, MV., Kicheva, MI., Stoinova, ZG. and Popova, LP., (2002). Two-Dimensional Electrophoretic Analysis of Salicylic Acid-Induced Changes in Polypeptide Pattern of Barley Leaves. Biologia plantarum. 45 (4), 585-588
Cismowski, MJ., Metodiev, M., Draper, E. and Stone, DE., (2001). Biochemical Analysis of Yeast G伪 Mutants That Enhance Adaptation to Pheromone. Biochemical and Biophysical Research Communications. 284 (2), 247-254
Metodiev, MV., (1998). Hornet venom induces abundant expression of specific polypeptides in young barley leaves. Journal of Experimental Botany. 49 (318), 27-32
Metodiev, MV., Tsonev, TD. and Popova, LP., (1996). Effect of jasmonic acid on the stomatal and nonstomatal limitation of leaf photosynthesis in barley leaves. Journal of Plant Growth Regulation. 15 (2), 75-80
METODIEV, M. and DEMIREVSKA-KEPOVA, K., (1992). Rubisco Quantitation in Leaves of Different Barley Varieties by Enzyme-Linked Immunosorbent Assay. Journal of Experimental Botany. 43 (2), 155-158
Conferences (7)
Pavlova, L., Farrar, D., Mani, J., Metodieva, G., Metodiev, M., Murray, P., Sizer, B. and Klenova, E., (2016). Levels of Serpin B1 protein in white blood cells of breast cancer patients increase in metastatic breast cancer
Mahmoud, O., Harrison, A., Gul, A., Khan, Z., Metodiev, MV. and Lausen, B., (2016).
Huete-Ortega, M., Lefebvre, SC., Metodieva, G., Metodiev, M. and Richard, GJ., (2015). PROTEOME PLASTICITY OF EMILIANIA HUXLEYI TO COMBINED CHANGES IN PCO2 AND NITROGEN SOURCE
Ismael, AC., Waszczak, N., Metodiev, M., Tian, W., Cao, Y., Liang, J., Suchkov, D., Bar, E., Arkowitz, R. and Stone, D., (2013). G尾 promotes polarization of the pheromone receptor by inhibiting its phosphorylation
Ismael, A., Waszczak, N., Metodiev, M., Tian, W., Cao, Y., Liang, J., Suchkov, D., Arkowitz, R. and Stone, D., (2012). Receptor phosphorylation and polarization are regulated by G尾 interaction with Yck1.
Metodiev, MV., (2011). Biomarkers research in Europe: focus on personalized medicine
Metodiev, MV., Timanova, A. and Stone, DE., (2004).
Grants and funding
2021
Integrating cellular space and time: interplays between subcellular organisation and lifespan
Biotechnology and Biological Sciences Research Council
Integrating cellular space and time: interplays between subcellular organisation and lifespan
Biotechnology and Biological Sciences Research Council
2016
Identifying the mechanisms and resource use implications of acclimation to high-temperature in marine cyanobacteria
Natural Environment Research Council
2011
Identification of new markers and drug candidates...
National Institute Of Health (Nih)
Structural restoration of Rhodopsin ADRP mutants
BRPS
2010
Identificaton of a human plasma component....
Breast Cancer Campaign
2009
Resource Utilization by Phytoplankton
Natural Environment Research Council
Contact
Academic support hours:
Friday 14:00-16:00
