Dr Andrea Mohr
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Email
amohr@essex.ac.uk -
Telephone
+44 (0) 1206 872540
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Location
3SW.5.21, Colchester Campus
Profile
Biography
My research is focused on cellular crosstalk in the tumour microenvironment leading to metastasis formation. I am especially interested in the role of mesenchymal stem cells (MSCs) in this process.
Qualifications
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PhD University of Hannover, (2000)
Appointments
糖心Vlog
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Senior Lecturer, 糖心Vlog (1/10/2023 - present)
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Director MSc Cancer Biology, 糖心Vlog (1/10/2020 - present)
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Lecturer in Cancer Biology, 糖心Vlog (1/10/2019 - 1/10/2023)
Other academic
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Senior Research Officer, 糖心Vlog (2013 - 2019)
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Senior Scientist, National University of Ireland, Galway (2009 - 2013)
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HRB Fellow, National University of Ireland, Galway (2006 - 2009)
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Post-doctoral Fellow, National University of Ireland, Galway (2005 - 2006)
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Post-doctoral Fellow, University of Ulm (2000 - 2005)
Research and professional activities
Research interests
Mesenchymal Stem Cells in Tumour Progression
Mesenchymal Stem Cell based Therapies
Teaching and supervision
Current teaching responsibilities
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Employability Skills for the Biosciences (BS211)
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Advanced Cancer Biology (BS932)
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Advanced Research Skills (BS953)
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Professional Skills and the Business of Biosciences (BS985)
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Research Project: MSc Cancer Biology (BS987)
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Research Project in Biomedical Science (BS831)
Current supervision
Previous supervision
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 24/8/2022
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 19/11/2021
Degree subject: Cell and Molecular Biology
Degree type: Master of Science (by Dissertation)
Awarded date: 3/11/2020
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 16/7/2020
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 5/2/2019
Publications
Journal articles (35)
Gundersen, RA., Chu, T., Abolfathi, K., Gokcen Dogan, S., Blair, PE., Nago, N., Hamblin, M., Brooke, GN., Zwacka, RM., Kafash Hoshiar, A. and Mohr, A., (2023). . Cancer Nanotechnology. 14 (1), 54-
Mohr, A., Chu, T., Clarkson, C., Brooke, G., Teif, V. and Zwacka, R., (2021). . Cancer Letters. 519, 63-77
Leach, DA., Mohr, A., Zwacka, R., Giottis, S., Yates, L., Lloyd, C., Brooke, GN. and Bevan, CL., (2021). Antiandrogens Target TMPRSS2 and Reduce SARS-CoV-2 Virus Entry in Lung Cells. Journal of the Endocrine Society. 5 (S1), A60-A61
Leach, DA., Mohr, A., Giotis, ES., Cil, E., Isac, AM., Yates, LL., Barclay, WS., Zwacka, RM., Bevan, CL. and Brooke, GN., (2021). . Nature Communications. 12 (1), 4068-
Mohr, A., Chu, T., Brooke, GN. and Zwacka, RM., (2019). . Cancers. 11 (4), 568-568
Mohr, A., Deedigan, L., Jencz, S., Mehrabadi, Y., Houlden, L., Albarenque, S-M. and Zwacka, RM., (2018). . Cell Death and Differentiation. 25 (2), 340-352
Mohr, A. and Zwacka, RM., (2018). . Cancer Letters. 414, 239-249
Mohr, A., Yu, R. and Zwacka, RM., (2015). . BMC Cancer. 15 (1), 494-
Arora, J., Zwacka, RM. and Mohr, A., (2015). Development of a FACS-based Smac/DIABLO release assay to monitor individual drug responses and to pave the way towards patient-tailored therapies. Journal of Inflammation. 12 (S1)
Yu, R., Albarenque, SM., Cool, RH., Quax, WJ., Mohr, A. and Zwacka, RM., (2014). . Cancer Biology & Therapy. 15 (12), 1658-1666
Yu, R., Deedigan, L., Albarenque, SM., Mohr, A. and Zwacka, RM., (2013). . Cell Death & Disease. 4 (2), e503-e503
Yu, R., Deedigan, L., Albarenque, SM., Mohr, A. and Zwacka, RM., (2013). Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects.. Cell death & disease. 4, creators-Mohr=3AAndrea=3A=3A
B眉neker, CK., Yu, R., Deedigan, L., Mohr, A. and Zwacka, RM., (2012). . Cancer Letters. 316 (2), 168-177
B锟絥eker, CK., Yu, R., Deedigan, L., Mohr, A. and Zwacka, RM., (2012). IFN-? combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells.. Cancer letters. 316 (2), 168-77
Albarenque, SM., Zwacka, RM. and Mohr, A., (2011). . Stem Cell Research. 7 (2), 163-171
Stadel, D., Mohr, A., Ref, C., MacFarlane, M., Zhou, S., Humphreys, R., Bachem, M., Cohen, G., M枚ller, P., Zwacka, RM., Debatin, K-M. and Fulda, S., (2010). . Clinical Cancer Research. 16 (23), 5734-5749
Mohr, A., Albarenque, SM., Deedigan, L., Yu, R., Reidy, M., Fulda, S. and Zwacka, RM., (2010). . Stem Cells. 28 (11), 2109-2120
Zwacka, (2009). . Oncology Reports. 21 (5), 1289-1295
H盲cker, S., Dittrich, A., Mohr, A., Schweitzer, T., Rutkowski, S., Krauss, J., Debatin, K-M. and Fulda, S., (2009). Histone deacetylase inhibitors cooperate with IFN-纬 to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Oncogene. 28 (35), 3097-3110
Mohr, A., B眉neker, C., Gough, RP. and Zwacka, RM., (2008). . Oncogene. 27 (6), 763-774
Murray, TVA., McMahon, JM., Howley, BA., Stanley, A., Ritter, T., Mohr, A., Zwacka, R. and Fearnhead, HO., (2008). . Journal of Cell Science. 121 (22), 3786-3793
Mohr, A., Lyons, M., Deedigan, L., Harte, T., Shaw, G., Howard, L., Barry, F., O'Brien, T. and Zwacka, R., (2008). . Journal of Cellular and Molecular Medicine. 12 (6b), 2628-2643
Murray, TVA., McMahon, JM., Howley, BA., Stanley, A., Ritter, T., Mohr, A., Zwacka, RM. and Fearnhead, HO., (2008). A non-apoptotic role for caspase-9 in muscle differentiation.. Journal of Cell Science. 121 (Pt 22), 3786-93
Mohr, A. and Zwacka, RM., (2007). . Cell Biology International. 31 (5), 526-530
Mohr, A., Lyons, M., Mohr, W. and Zwacka, R., (2007). Gentherapeutische Strategien gegen das kolorektale Karzinom. DMW - Deutsche Medizinische Wochenschrift. 132 (11), 567-570
Mohr, A., Lyons, M., Mohr, W. and Zwacka, R., (2007). Gentherapeutische Strategien gegen das kolorektale Karzinom. TumorDiagnostik & Therapie. 28 (3), 129-132
Mohr, A., Lyons, M., Mohr, W. and Zwacka, RM., (2007). . Deutsche medizinische Wochenschrift (1946). 132 (11), 567-570
Braeuer, SJ., Bu虉neker, C., Mohr, A. and Zwacka, RM., (2006). . Molecular Cancer Research. 4 (10), 715-728
Behrend, L., Mohr, A., Dick, T. and Zwacka, RM., (2005). . Molecular and Cellular Biology. 25 (17), 7758-7769
Mohr, A., Zwacka, RM., Jarmy, G., B眉neker, C., Schrezenmeier, H., D枚hner, K., Beltinger, C., Wiesneth, M., Debatin, K-M. and Stahnke, K., (2005). . Oncogene. 24 (14), 2421-2429
Mohr, A., Zwacka, RM., Debatin, K-M. and Stahnke, K., (2004). A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release. Cell Death & Differentiation. 11 (10), 1153-1154
Mohr, A., Henderson, G., Dudus, L., Herr, I., Kuerschner, T., Debatin, K-M., Weiher, H., Fisher, KJ. and Zwacka, RM., (2004). . Gene Therapy. 11 (6), 534-543
Stahnke, K., Mohr, A., Liu, J., Meyer, LH., Karawajew, L. and Debatin, K-M., (2004). Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis. Apoptosis. 9 (4), 457-465
Stahnke, K., Eckhoff, S., Mohr, A., Meyer, LH. and Debatin, K-M., (2003). Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells. Leukemia. 17 (11), 2130-2139
Stefan, M., Koch, A., Mancini, A., Mohr, A., Weidner, KM., Niemann, H. and Tamura, T., (2001). Src Homology 2-containing Inositol 5-Phosphatase 1 Binds to the Multifunctional Docking Site of c-Met and Potentiates Hepatocyte Growth Factor-induced Branching Tubulogenesis. Journal of Biological Chemistry. 276 (5), 3017-3023
Conferences (6)
Mohr, A., Tianyuan, C., Brooke, G. and Zwacka, RM., (2021). SOLUBLE TRAIL HAS BETTER EFFICACY THAN FULL-LENGTH MEMBRANE-BOUND TRAIL, AND IN COMBINATION WITH AKTI BLOCKS PRO-METASTATIC CYTOKINE PRODUCTION IN PROSTATE CANCER CELLS
Albarenque, SM., Mohr, A., Rui, Y., Reidy, M., Zwacka, RM. and Laura, LD., (2010). RNAi-Mediated Inhibition of XIAP Combined with Systemic Mesenchymal Stem Cell-mediated Delivery of STRAIL Inhibits Metastatic Growth of Pancreatic Carcinoma Cells
Mohr, A., Behrend, L. and Zwacka, RM., (2006). Overexpression of MnSOD induces mitochondrial depolarization and p53-dependent senescence
Mohr, A., Debatin, KM. and Zwacka, RM., (2003). 5-fluorouracil induced apoptotis inhuman colon cancer cells is mediated by caspase-8 and-2 and inhibition of thymidilate synthase in p53 deficient cells.
Mohr, A., Zwacka, RM., Schrezenmeier, H., D枚hner, K., Wiesneth, M., Stahnke, K. and Debatin, KM., (2003). Caspase-8L expression contributes to the protection of CD34+hematopoietic progenitor cells from C95-mediated apoptosis.
Mohr, A., Henderson, G., Dudus, L., Herr, I., Debatin, KM., Weiher, H., Fisher, K. and Zwacka, RM., (2003). AAV encoded expression of TRAIL in experimental human colorectal tumor cells leads to tumor regression.
Reports and Papers (1)
Mohr, A., Tianyuan, C., Clarkson, CT., Brooke, GN., Teif, VB. and Zwacka, RM., (2020). Fas-threshold signalling in MSCs causes tumour progression and metastasis
Grants and funding
2024
Next-generation liquid biopsies for early detection of pancreatic cancer based on cell-free DNA nucleosomics
Pancreatic Cancer UK
A translational research radiation facility to tackle cancer and viral infections
Sir Jules Thorn Charitable Trust
A new generation of liquid biopsies for early diagnostics of colorectal cancer
Bowel Cancer UK
2023
Optimisation of exosome-based therapies from 3D BioPrinted stem cell structures
糖心Vlog (BBSRC IAA)
2022
ESNEFT Haematology PhD studentship Biomedical Unit
East Suffolk and North 糖心Vlog NHS Foundation Trust
Rapid and Agile Project Fund - The development of therapeutics for COVID-19 variants
糖心Vlog
