Dr Charalampos (Babis) Rallis
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Email
c.rallis@essex.ac.uk -
Location
Colchester Campus
Profile
Biography
The Rallis Lab uses Systems Biology approaches in fission yeast and human tissue culture systems to investigate the molecular basis of cellular fitness, cancer and ageing with a focus on the nutrient-responsive signalling pathway Target of Rapamycin (TOR). The aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases. Finally, the group performs quantitative fitness profiling of microbiomes and mycobiomes and explore the effects of nutrition on biome physiology and subsequent effects on human healthy ageing. Self-funded students, or candidates interested in applying for fellowships to undertake research on cellular ageing and mechanisms underlying age-related disease in my laboratory, are welcome to contact Babis (c.rallis@essex.ac.uk) at any time. LABORATORY WEBSITE and further information on our work: www.rallislab.org CURRENT GROUP MEMBERS Charalampos (Babis) Rallis: Group Leader Julie Arvidson: Departmental Technician and Laboratory Manager Lynwen James: Laboratory Technician and Tissue Culture Manager Aleksandra (Ola) Dabrowska: Postdoctoral Research Associate Juhi Kumar: Postdoctoral Research Associate (Specialist Technician) Rowshan Islam: Postdoctoral Research Associate (Specialist Technician) John-Patrick Alao: Postdoctoral Research Associate Luc Legon: PhD Student Riaz Somji: PhD Student (Shared with Giotis Lab) Anne-Marie Tricolici: MSD Student Babis is a Principal Investigator and Reader in Molecular Genetics of Ageing at 糖心Vlog, Associate Lecturer in Cell and Molecular Biology at Birkbeck College, University of London and Fellow of the Higher Education Academy. PROFESSIONAL ACTIVITIES: -BBSRC Pool of Experts and Committee Membership -Executive Agency for Higher Education Research Development and Innovation Funding (UEFISCDI) committee PED Committee / Panel membership -National Science Centre, Poland-Panel NZ3: Cellular and developmental biology Committee / Panel membership -Biochemical Society Research Area I: genes Committee / Panel membership -Israel Science Foundation Pool of Experts Membership. -Greek Foundation of Research and Innovation, pool of experts Membership -Scientific Reports, Editorial Board Membership -British Society for Cell Biology, Professional Membership -British Society for Developmental Biology, Professional Membership -External Examiner, MSc in Genetics and Genomics, Oxford Brookes University
Qualifications
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PhD in Genetics and Developmental Biology National Institute for Medical Research,
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MRes in Molecular Biology and Biomedicine University of Crete,
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BSc in Biology University of Crete,
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Fellow Higher Education Academy,
Appointments
糖心Vlog
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Reader in Molecular Genetics of Ageing, School of Life Sciences, 糖心Vlog (1/10/2022 - present)
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Lecturer (R) in Molecular Genetics of Ageing, School of Life Sciences, 糖心Vlog (20/4/2020 - 30/9/2022)
Other academic
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Honorary Lecturer, Genetics, Evolution and Environment, University College London (4/1/2016 - 4/1/2022)
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Associate Lecturer, Biological Sciences, Birkbeck College, University of London (4/2/2008 - present)
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Research Committee Area I: Genes Member, Biochemical Society (1/2/2021 - present)
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External Examiner, MSc in Genetics and Genomics, Oxford Brookes University (1/10/2020 - present)
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Senior Lecturer in Biochemistry, Biosciences, University of East London (4/1/2016 - 19/4/2020)
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Research Associate, University College London (19/4/2009 - 3/1/2016)
Research and professional activities
Research interests
Transcriptional networks in ageing and neurodegeneration
Integrating cellular space and time in physiology, disease and ageing
Dissection of genetic interactomes in cancer and ageing
Fitness analysis of microbiomes in response to different nutritional regimes
Current research
Transcriptional networks in ageing and neurodegeneration
Using 2D and 3D human neuronal cultures and analysing gene and protein networks in normal and pathological conditions.
Dissection of genetic interactomes in cancer and ageing
Genome-wide cellular phenomics approaches coupled with computational analysis towards identifying gene-gene, gene-drug and drug-drug interactions important in ageing and disease.
Fitness analysis of microbiomes in response to different nutritional regimes
Using species-agnostic phenotyping platforms to quantify fitness growth and physiology of microbiota and mycobiota relevant to host lifelong health.
Integrating cellular space and time in physiology, disease and ageing
Utilising yeast and human cellular models and dissecting the effects of diverse inputs in ageing and lifespan regulation.
Conferences and presentations
mTOR dysregulation in human nasal epithelial cells infected by the seasonal coronavirus NL63
Annual conference of Microbiology Society 2023, 17/4/2023
Teaching and supervision
Previous supervision
Degree subject: Cell and Molecular Biology
Degree type: Master of Science (by Dissertation)
Awarded date: 29/4/2024
Publications
Publications (2)
Kumar, J. and Rallis, C., (2024). Rapalink-1 reveals novel mTOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating mTOR activity and lifespan
Alao, J-P., Kumar, J., Stamataki, D. and Rallis, C., (2022). Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
Journal articles (56)
Alao, J-P., Legon, L., Dabrowska, A., Tricolici, A-M., Kumar, J. and Rallis, C., (2023). . Cells. 12 (4), 519-519
Gal, C., Cochrane, GA., Morgan, BA., Rallis, C., B盲hler, J. and Whitehall, SK., (2023). The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone. Cell Cycle. 22 (17), 1921-1936
Islam, RA. and Rallis, C., (2023). Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes. 7 (3), 17-17
Islam, RA. and Rallis, C., (2023). Correction: Islam, R.A.; Rallis, C. Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes 2023, 7, 17. Epigenomes. 7 (4), 26-26
Legon, L. and Rallis, C., (2022). . Briefings in Functional Genomics. 21 (1), 4-12
Dabrowska, A., Kumar, J. and Rallis, C., (2022). . Cells. 11 (9), 1568-1568
Rallis, C., M眉lleder, M., Smith, G., Au, YZ., Ralser, M. and B盲hler, J., (2021). . Journals of Gerontology - Series A. 76 (2), 205-210
Alao, J-P., Legon, L. and Rallis, C., (2021). . Cells. 10 (2), 305-305
Martinez-Miguel, VE., Lujan, C., Espie--Caullet, T., Martinez-Martinez, D., Moore, S., Backes, C., Gonzalez, S., Galimov, ER., Brown, AEX., Halic, M., Tomita, K., Rallis, C., von der Haar, T., Cabreiro, F. and Bjedov, I., (2021). . Cell Metabolism. 33 (11), 2288-2300.e12
Rallis, C., M眉lleder, M., Smith, G., Au, YZ., Ralser, M. and B盲hler, J., (2021). Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast
Rodr铆guez-L贸pez, M., Gonzalez, S., Hillson, O., Tunnacliffe, E., Codlin, S., Tallada, VA., B盲hler, J. and Rallis, C., (2020). . Cell Reports. 30 (10), 3240-3249.e4
Bjedov, I. and Rallis, C., (2020). . Genes. 11 (9), 1043-1043
Alao, JP., Johansson-Sj枚lander, J., Rallis, C. and Sunnerhagen, P., (2020). . Microorganisms. 8 (10), 1512-1512
Pai, C-C., Hsu, K-F., Durley, SC., Keszthelyi, A., Kearsey, SE., Rallis, C., Folkes, LK., Deegan, R., Wilkins, SE., Pfister, SX., De Le贸n, N., Schofield, CJ., B盲hler, J., Carr, AM. and Humphrey, TC., (2019). . Journal of Cell Science. 132 (6), jcs226969-
Rodriguez-Lopez, M., Gonzalez, S., Hillson, O., Tunnacliffe, E., Codlin, S., Tallada, V., Bahler, J. and Rallis, C., (2019). . bioarxiv
Pai, C-C., Hsu, K-F., Durley, SC., Keszthelyi, A., Kearsey, SE., Rallis, C., Folkes, LK., Deegan, R., Wilkins, SE., Pfister, SX., Le贸n, ND., Schofield, CJ., B盲hler, J., Carr, AM. and Humphrey, TC., (2019). An essential role for dNTP homeostasis following CDK-induced replication stress
Hillson, O., Gonzalez, S. and Rallis, C., (2018). . BioMolecular Concepts. 9 (1), 200-215
Ellis, DA., Mustonen, V., Rodr铆guez-L贸pez, M., Rallis, C., Malecki, M., Jeffares, DC. and B盲hler, J., (2018). . Genetics. 210 (2), 733-744
Atkinson, SR., Marguerat, S., Bitton, DA., Rodr铆guez-L贸pez, M., Rallis, C., Lemay, J-F., Cotobal, C., Malecki, M., Smialowski, P., Mata, J., Korber, P., Bachand, F. and B盲hler, J., (2018). . RNA. 24 (9), 1195-1213
Ellis, DA., Mustonen, V., Rodr铆guez-L贸pez, M., Rallis, C., Malecki, M., Jeffares, DC. and B盲hler, J., (2018). Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells
Hoyos-Manchado, R., Reyes-Mart铆n, F., Rallis, C., Gamero-Est茅vez, E., Rodr铆guez-G贸mez, P., Quintero-Blanco, J., B盲hler, J., Jim茅nez, J. and Tallada, VA., (2017). . Scientific Reports. 7 (1), 15895-
Gonzalez, S. and Rallis, C., (2017). . Frontiers in Cell and Developmental Biology. 5 (JUN), 61-
Rallis, C., Townsend, S. and B盲hler, J., (2017). . Scientific Reports. 7 (1), 44257-
Jeffares, DC., Jolly, C., Hoti, M., Speed, D., Shaw, L., Rallis, C., Balloux, F., Dessimoz, C., B盲hler, J. and Sedlazeck, FJ., (2017). . Nature Communications. 8 (1), 14061-
Atkinson, SR., Marguerat, S., Bitton, DA., Rodr铆guez-L贸pez, M., Rallis, C., Lemay, J-F., Cotobal, C., Malecki, M., Mata, J., Bachand, F. and B盲hler, J., (2017). Long non-coding RNA repertoire and regulation by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeast
Malecki, M., Bitton, DA., Rodr铆guez-L贸pez, M., Rallis, C., Calavia, NG., Smith, GC. and B盲hler, J., (2016). . Genome Biology. 17 (1), 240-
Brault, A., Rallis, C., Normant, V., Garant, J-M., B盲hler, J. and Labb茅, S., (2016). . G3: Genes, Genomes, Genetics. 6 (10), 3077-3095
Rallis, C. and B盲hler, J., (2016). . Critical Reviews in Biochemistry and Molecular Biology. 51 (2), 86-95
Tomalin, LE., Day, AM., Underwood, ZE., Smith, GR., Dalle Pezze, P., Rallis, C., Patel, W., Dickinson, BC., B盲hler, J., Brewer, TF., Chang, CJ-L., Shanley, DP. and Veal, EA., (2016). . Free Radical Biology and Medicine. 95, 333-348
Vishwanatha, A., Rallis, C., Bevkal Subramanyaswamy, S., D'Souza, CJM., B盲hler, J. and Schweingruber, ME., (2016). . FEMS Yeast Research. 16 (6), fow061-fow061
Bischof, L., P艡evorovsk媒, M., Rallis, C., Jeffares, DC., Arzhaeva, Y. and B盲hler, J., (2016). . BioTechniques. 61 (4), 191-201
Jeffares, DC., Jolly, C., Hoti, M., Speed, D., Shaw, L., Rallis, C., Balloux, F., Dessimoz, C., B盲hler, J. and Sedlazeck, FJ., (2016). Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
Malecki, M., Bitton, DA., Rodriguez-Lopez, M., Rallis, C., Garcia Cavalia, N., Smith, GC. and Bahler, J., (2016). Functional and Regulatory Profiling of Energy Metabolism in Fission Yeast
Bond, M., Brown, R., Rallis, C., Bahler, J. and Mole, S., (2015). . Microbial Cell. 2 (12), 466-480
Jeffares, DC., Rallis, C., Rieux, A., Speed, D., P艡evorovsk媒, M., Mourier, T., Marsellach, FX., Iqbal, Z., Lau, W., Cheng, TMK., Pracana, R., M眉lleder, M., Lawson, JLD., Chessel, A., Bala, S., Hellenthal, G., O'Fallon, B., Keane, T., Simpson, JT., Bischof, L., Tomiczek, B., Bitton, DA., Sideri, T., Codlin, S., Hellberg, JEEU., van Trigt, L., Jeffery, L., Li, J-J., Atkinson, S., Thodberg, M., Febrer, M., McLay, K., Drou, N., Brown, W., Hayles, J., Carazo Salas, RE., Ralser, M., Maniatis, N., Balding, DJ., Balloux, F., Durbin, R. and B盲hler, J., (2015). . Nature Genetics. 47 (3), 235-241
Bitton, DA., Atkinson, SR., Rallis, C., Smith, GC., Ellis, DA., Chen, YYC., Malecki, M., Codlin, S., Lemay, J-F., Cotobal, C., Bachand, F., Marguerat, S., Mata, J. and B盲hler, J., (2015). . Genome Research. 25 (6), 884-896
Sideri, T., Rallis, C., Bitton, DA., Lages, BM., Suo, F., Rodr铆guez-L贸pez, M., Du, L-L. and B盲hler, J., (2015). . G3: Genes, Genomes, Genetics. 5 (1), 145-155
Bitton, DA., Rallis, C., Jeffares, DC., Smith, GC., Chen, YYC., Codlin, S., Marguerat, S. and B盲hler, J., (2014). . Genome Research. 24 (7), 1169-1179
Sofola-Adesakin, O., Castillo-Quan, JI., Rallis, C., Tain, LS., Bjedov, I., Rogers, I., Li, L., Martinez, P., Khericha, M., Cabecinha, M., B盲hler, J. and Partridge, L., (2014). . Frontiers in Aging Neuroscience. 6 (JUL), 190-
Rallis, C., L贸pez-Maury, L., Georgescu, T., Pancaldi, V. and B盲hler, J., (2014). . Biology Open. 3 (2), 161-171
Bitton, DA., Atkinson, SR., Rallis, C., Smith, GC., Ellis, DA., Jeffares, DC., Chen, YYC., Malecki, M., Codlin, S., Lubas, M., Lemay, J-F., Bachand, F., Cotobal, C., Marguerat, S., Mata, J., Heick Jensen, T. and B盲hler, J., (2014). Skip and bin: pervasive alternative splicing triggers degradation by nuclear RNA surveillance in fission yeast
Rallis, C. and B盲hler, J., (2013). . Aging. 5 (5), 335-336
Rallis, C., Codlin, S. and B盲hler, J., (2013). . Aging Cell. 12 (4), 563-573
Pancaldi, V., Sara莽, OS., Rallis, C., McLean, JR., P艡evorovsk媒, M., Gould, K., Beyer, A. and B盲hler, J., (2012). . G3: Genes, Genomes, Genetics. 2 (4), 453-467
P艡evorovsk媒, M. and Rallis, C., (2011). . Genome Biology. 12 (5), 305-305
Rallis, C., Pinchin, SM. and Ish-Horowicz, D., (2010). . Development. 137 (21), 3591-3601
Maydan, M., McDonald, PC., Sanghera, J., Yan, J., Rallis, C., Pinchin, S., Hannigan, GE., Foster, LJ., Ish-Horowicz, D., Walsh, MP. and Dedhar, S., (2010). . PLoS One. 5 (8), e12356-e12356
Rallis, C., (2009). . Genome Biology. 10 (9), 315-315
Hanisch, A., Vezzaro, A. and Rallis, C., (2008). . Genome Biology. 9 (6), 310-310
Bazigou, E. and Rallis, C., (2007). . Genome Biology. 8 (7), 310-310
Rallis, C., (2007). . Genome Biology. 8 (5), 306-306
Rallis, C., (2006). . Genome Biology. 7 (10), 329-329
Rallis, C., Del Buono, J. and Logan, MPO., (2005). . Development. 132 (8), 1961-1970
Rallis, C., Bruneau, BG., Del Buono, J., Seidman, CE., Seidman, JG., Nissim, S., Tabin, CJ. and Logan, MPO., (2003). . Development. 130 (12), 2741-2751
Rallis, CP. and Burand, JP., (2002). . Journal of Invertebrate Pathology. 81 (1), 33-44
Rallis, C., Stamataki, D., Pontikakis, S., Mankoo, BS. and Karagogeos, D., (2001). . Mechanisms of Development. 104 (1-2), 121-124
Thesis dissertation (1)
Rallis, C., (2004). T-box genes in limb development and disease.
Grants and funding
2021
Integrating cellular space and time: interplays between subcellular organisation and lifespan
Biotechnology and Biological Sciences Research Council
Mechanisms of uncoupling cellular growth from nutrient availability and mTOR pathway activity
Medical Research Council
2020
TOR-dependent gene and protein networks in neurodegeneration
The Royal Society
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