Dr Dimitri Svistunenko

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Email
svist@essex.ac.uk -
Telephone
+44 (0) 1206 873149
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Location
3SW.5.05, Colchester Campus
Profile
Biography
2020-present Senior Lecturer, School of Life Sciences, 糖心Vlog 2015-2020 Lecturer, School of Life Sciences, 糖心Vlog 2008-present Director, Biomedical EPR Facility, Department of Biological Sciences / School of Life Sciences, 糖心Vlog 1995-2008 Research Officer, Department of Biological Sciences, 糖心Vlog 1994-1995 Visiting staff, Department of Biological Sciences, 糖心Vlog 1984-1994 Research Associate, Institute of Chemical Physics, Russian Academy of Sciences, Moscow BIOMEDICAL EPR FACILITY AT THE UNIVERSITY OF ESSEX Electron Paramagnetic Resonance (EPR) spectroscopy is a powerful method in biology, chemistry, medicine and many other areas... (To read more, follow this link: /departments/life-sciences/research/protein-structure-and-mechanisms-of-disease-group/biomedical-epr-facility). THE DATABASE OF THE PHENOL RING ROTATION ANGLE IN TYROSINES IN DIFFERENT PROTEINS An EPR spectrum of a tyrosine radical in a protein depends strongly on the rotational orientation of the phenoxyl ring. By looking in the protein structure at the orientations of these rings in different tyrosines, the site of the radical can be identified. (Read more at https://svistunenko.essex.ac.uk/lev1/tyrdb/home.shtml). WHAT IS EPR? The basics of the resonance phenomenon are illustrated in a moving picture (/departments/life-sciences/research/protein-structure-and-mechanisms-of-disease-group/biomedical-epr-facility/what-is-epr). EPR SPECTRA SIMULATION FUN First ever clickable EPR spectra simulation tool (https://svistunenko.essex.ac.uk/lev1/EPR_fun.shtml). THE g-FACTORS OF HAEM PROTEINS A table comprising reported values of g-factors of the high spin and low spin forms of haem iron (https://svistunenko.essex.ac.uk/lev1/Haem_g_factors.shtml).
Qualifications
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2017 Fellow of the Higher Education Academy
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2000 The European Computer Driving Licence (ECDL). IT skills beyond the ECDL curriculum include: HTML, Perl, CGI-scripting, MatLab, Visual Basic, various image packages including those for molecular modelling, Gaussian03. I am hosting a scientific on-line database.
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1984 Candidate of Sciences (Physics and Maths), Institute of Chemical Physics / Moscow Institute of Physics and Technology / Moscow State University
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1981 Red (honour) Diploma in Physics and Engineering, Moscow Institute of Physics and Technology
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PhD in Physics and Maths Moscow Institute of Physics and Technology / Institute of Chemical Physics, Russian Academy of Sciences / Moscow State University,
Research and professional activities
Research interests
My research interests are centred on proteins and enzymes with particular reference to their paramagnetism. A molecule is called paramagnetic if it has an odd number of electrons. Usually, electrons in molecules come in pairs, so an even number of electrons in most chemical structures is typical. But for many biologically important molecules involved in redox reactions, there must exist states which are one electron more or one electron less than the stable even number of electrons state. These molecular states of odd number of electrons (the paramagnetic states!) are chemically active and are major players in proteins and enzymes mechanisms. Thus we study these states of enzymes and proteins to understand how they work and to elucidate their role in normal metabolism and in some pathological situations.
Haptoglobin complex with haemoglobin
Haem containing globins
Ferritins
Current research
Dye decolourising peroxidases
Bacterial copper enzymes
Teaching and supervision
Current teaching responsibilities
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Inorganic and Physical Chemistry (BS133)
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Transferable Skills in Life Sciences (BS143)
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Employability Skills for the Biosciences (BS211)
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Biomembranes and Bioenergetics (BS332)
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Industrial Biotechnology (BS937)
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Advanced Research Skills (BS953)
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Research Project: MSc Biotechnology (BS984)
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Professional Skills and the Business of Biosciences (BS985)
Previous supervision

Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 7/2/2022

Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 24/4/2020
Publications
Journal articles (123)
Mackievic, V., Li, Y., Hryvusevich, P., Svistunenko, D., Seregin, I., Kozhevnikova, A., Kartashov, A., Shabala, S., Samokhina, V., Rusakovich, A., Cuin, TA., Sokolik, A., Li, X., Huang, X., Yu, M. and Demidchik, V., (2025). L-histidine makes Ni2+ 鈥榲isible鈥 for plant signalling systems: Shading the light on Ni2+-induced Ca2+ and redox signalling in plants. Plant Physiology and Biochemistry. 220, 109227-109227
Pullin, J., Rodr铆guez-Celma, J., Franceschetti, M., Mundy, JEA., Svistunenko, DA., Bradley, JM., Le Brun, NE. and Balk, J., (2025). Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins. Nature Communications. 16 (1), 3865-
Reeder, BJ., Svistunenko, DA. and Wilson, MT., (2024). . International Journal of Molecular Sciences. 25 (12), 6794-6794
Fujii, S., Wilson, MT., Adams, HR., Mikolajek, H., Svistunenko, DA., Smyth, P., Andrew, CR., Sambongi, Y. and Hough, MA., (2024). Conformational rigidity of cytochrome c'-伪 from a thermophile is associated with slow NO binding. Biophysical Journal. 123 (16), 2594-2603
Reeder, B., Deganutti, G., Ukeri, J., Atanasio, S., Svistunenko, D., Ronchetti, C., Mobarec, JC., Welbourn, E., Asaju, J., Vos, M., Wilson, M. and Reynolds, C., (2024). . Chemical Science. 15 (18), 6738-6751
Nash, BW., Fernandes, TM., Burton, JAJ., Morgado, L., van Wonderen, JH., Svistunenko, DA., Edwards, MJ., Salgueiro, CA., Butt, JN. and Clarke, TA., (2024). Tethered heme domains in a triheme cytochrome allow for increased electron transport distances. Protein Science. 33 (11), e5200-
Bradley, JM., Bugg, Z., Sackey, A., Andrews, SC., Wilson, MT., Svistunenko, DA., Moore, GR. and Le Brun, NE., (2024). . Angewandte Chemie International Edition. 63 (16), e202401379-
Adams, HR., Svistunenko, DA., Wilson, MT., Fujii, S., Strange, RW., Hardy, ZA., Vazquez, PA., Dabritz, T., Streblow, GJ., Andrew, CR. and Hough, MA., (2023). . Journal of Biological Chemistry. 299 (6), 104742-104742
Lu膷i膰, M., Wilson, MT., Pullin, J., Hough, MA., Svistunenko, DA. and Worrall, JAR., (2023). New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase. Chemical Science. 14 (44), 12518-12534
Svistunenko, DA., Pullin, J., Bradley, J., Moore, G., Le Brun, N. and Wilson, M., (2021). . Angewandte Chemie International Edition. 60 (15), 8376-8379
Pullin, J., Wilson, MT., Cl茅mancey, M., Blondin, G., Bradley, JM., Moore, GR., Le Brun, NE., Lu膷i膰, M., Worrall, JAR. and Svistunenko, DA., (2021). . Angewandte Chemie International Edition. 60 (15), 8361-8369
Lu膷i膰, M., Wilson, MT., Svistunenko, DA., Owen, RL., Hough, MA. and Worrall, JAR., (2021). . Journal of Biological Inorganic Chemistry. 26 (7), 743-761
Hindson, SA., Bunzel, HA., Frank, B., Svistunenko, DA., Williams, C., van der Kamp, MW., Mulholland, AJ., Pudney, CR. and Anderson, JLR., (2021). . ACS Catalysis. 11 (18), 11532-11541
Svistunenko, DA., (2021). . Journal of biomedical research. 35 (4), 294-300
Lucic, M., Chaplin, AK., Moreno-Chicano, T., Dworkowski, F., Wilson, M., Svistunenko, D., Hough, M. and Worrall, JAR., (2020). . Dalton Transactions. 49 (5), 1620-1636
Svistunenko, DA. and Manole, A., (2020). Tyrosyl radical in haemoglobin and haptoglobin-haemoglobin complex: how does haptoglobin make haemoglobin less toxic?. The Journal of Biomedical Research. 34 (4), 281-281
Lucic, M., Svistunenko, D., Wilson, M., Chaplin, A., Davy, B., Ebrahim, A., Axford, D., Tosha, T., Sugimoto, H., Owada, S., Dworkowski, F., Tews, I., Owen, R., Hough, M. and Worrall, JAR., (2020). . Angewandte Chemie International Edition. 59 (48), 21656-21662
Bradley, JM., Svistunenko, DA., Wilson, MT., Hemmings, AM., Moore, GR. and Le Brun, NE., (2020). . The Journal of Biological Chemistry. 295 (51), 17602-17623
Bradley, JM., Pullin, J., Moore, GR., Svistunenko, DA., Hemmings, AM. and Le Brun, NE., (2020). . Dalton Transactions. 49 (5), 1545-1554
Lu膷i膰, M., Svistunenko, DA., Wilson, MT., Chaplin, AK., Davy, B., Ebrahim, A., Axford, D., Tosha, T., Sugimoto, H., Owada, S., Dworkowski, FSN., Tews, I., Owen, RL., Hough, MA. and Worrall, JAR., (2020). Serial Femtosecond Zero Dose Crystallography Captures a Water鈥怓ree Distal Heme Site in a Dye鈥怐ecolorising Peroxidase to Reveal a Catalytic Role for an Arginine in FeIV=O Formation. Angewandte Chemie. 132 (48), 21840-21846
Jabeen, A., Reeder, BJ., Svistunenko, D., Hisaindee, S., Ashraf, S., Al-Zuhair, S. and Battah, S., (2019). . IRBM. 40 (1), 51-61
Adams, HR., Krewson, C., Vardanega, JE., Fujii, S., Moreno-Chicano, T., Sambongi, Y., Svistunenko, D., Paps, J., Andrew, CR. and Hough, MA., (2019). . Chemical Science. 10 (10), 3031-3041
Chaplin, AK., Chicano, TM., Hampshire, BV., Wilson, MT., Hough, MA., Svistunenko, DA. and Worrall, JAR., (2019). . Chemistry 鈥 A European Journal. 25 (24), 6141-6153
Bennett, SP., Soriano-Laguna, MJ., Bradley, JM., Svistunenko, DA., Richardson, DJ., Gates, AJ. and Le Brun, NE., (2019). . Chemical Science. 10 (19), 4985-4993
Adams, HR., Krewson, C., Vardanega, JE., Fujii, S., Moreno-Chicano, T., Sambongi, Y., Svistunenko, D., Paps, J., Andrew, CR. and Hough, MA., (2019). Correction: One fold, two functions: cytochrome P460 and cytochrome c鈥-尾 from the methanotroph Methylococcus capsulatus (Bath). Chemical Science. 10 (36), 8490-8490
Freeman, SL., Kwon, H., Portolano, N., Parkin, G., Venkatraman Girija, U., Basran, J., Fielding, AJ., Fairall, L., Svistunenko, DA., Moody, PCE., Schwabe, JWR., Kyriacou, CP. and Raven, EL., (2019). . Proceedings of the National Academy of Sciences. 116 (40), 19911-19916
Bradley, J., Svistunenko, D., Pullin, J., Hill, N., Stuart, R., Palenik, B., Wilson, M., Hemmings, A., Moore, G. and Le Brun, N., (2019). . Proceedings of the National Academy of Sciences. 116 (6), 2058-2067
Pellicer Martinez, MT., Crack, JC., Stewart, MY., Bradley, JM., Svistunenko, DA., Johnston, AW., Cheesman, MR., Todd, JD. and Le Brun, NE., (2019). . eLife. 8, e47804-
Carey, LM., Gavenko, R., Svistunenko, DA. and Ghiladi, RA., (2018). . Biochimica et Biophysica Acta - Proteins and Proteomics. 1866 (2), 230-241
Deacon, OM., Svistunenko, DA., Moore, GR., Wilson, MT. and Worrall, JAR., (2018). . Biochemistry. 57 (29), 4276-4288
Makavitskaya, M., Svistunenko, D., Navaselsky, I., Hryvusevich, P., Mackievic, V., Rabadanova, C., Tyutereva, E., Samokhina, V., Straltsova, D., Sokolik, A., Voitsekhovskaja, O. and Demidchik, V., (2018). Novel roles of ascorbate in plants: induction of cytosolic Ca2+ signals and efflux from cells via anion channels. Journal of Experimental Botany. 69 (14), 3477-3489
Child, SA., Bradley, JM., Pukala, TL., Svistunenko, DA., Le Brun, NE. and Bell, SG., (2018). . Chemical Science. 9 (41), 7948-7957
Chaplin, AK., Svistunenko, DA., Hough, MA., Wilson, MT., Vijgenboom, E. and Worrall, JAR., (2017). . The Biochemical Journal. 474 (5), 809-825
Chaplin, AK., Bernini, C., Sinicropi, A., Basosi, R., Worrall, JAR. and Svistunenko, DA., (2017). . Angewandte Chemie International Edition. 129 (23), 6602-6606
Al-Zuhair, S., Ashraf, S., Hisaindee, S., Darmaki, NA., Battah, S., Svistunenko, D., Reeder, BJ., Stanway, G. and Chaudhary, A., (2017). . Engineering in Life Sciences. 17 (2), 175-185
Bradley, JM., Svistunenko, DA., Moore, GR. and Le Brun, NE., (2017). . Metallomics. 9 (10), 1421-1428
Pellicer Martinez, MT., Martinez, AB., Crack, JC., Holmes, JD., Svistunenko, DA., Johnston, AWB., Cheesman, MR., Todd, JD. and Le Brun, NE., (2017). . Chemical Science. 8 (12), 8451-8463
Chaplin, AK., Bernini, C., Sinicropi, A., Basosi, R., Worrall, JAR. and Svistunenko, DA., (2017). Tyrosine or Tryptophan? Modifying a Metalloradical Catalytic Site by Removal of the Cys鈥揟yr Cross鈥怢ink in the Galactose 6鈥怬xidase Homologue GlxA. Angewandte Chemie. 129 (23), 6602-6606
Chaplin, AK., Wilson, MT., Hough, MA., Svistunenko, DA., Hemsworth, GR., Walton, PH., Vijgenboom, E. and Worrall, JAR., (2016). . Journal of Biological Chemistry. 291 (24), 12838-12850
Munnoch, JT., Martinez, MTP., Svistunenko, DA., Crack, JC., Le Brun, NE. and Hutchings, MI., (2016). . Scientific Reports. 6 (1), 31597-
Nnamchi, CI., Parkin, G., Efimov, I., Basran, J., Kwon, H., Svistunenko, DA., Agirre, J., Okolo, BN., Moneke, A., Nwanguma, BC., Moody, PCE. and Raven, EL., (2016). . Journal of Biological Inorganic Chemistry. 21 (1), 63-70
Crack, JC., Svistunenko, DA., Munnoch, J., Thomson, AJ., Hutchings, MI. and Le Brun, NE., (2016). . Journal of Biological Chemistry. 291 (16), 8663-8672
Sosan, A., Svistunenko, D., Straltsova, D., Tsiurkina, K., Smolich, I., Lawson, T., Subramaniam, S., Golovko, V., Anderson, D., Sokolik, A., Colbeck, I. and Demidchik, V., (2016). . The Plant Journal. 85 (2), 245-257
Wareham, LK., Begg, R., Jesse, HE., Van Beilen, JWA., Ali, S., Svistunenko, DA., McLean, S., Hellingwerf, KJ., Sanguinetti, G. and Poole, RK., (2016). . Antioxidants & Redox Signaling. 24 (17), 1013-1028
Chaplin, AK., Petrus, MLC., Mangiameli, G., Hough, MA., Svistunenko, DA., Nicholls, P., Claessen, D., Vijgenboom, E. and Worrall, JAR., (2015). . Biochemical Journal. 469 (3), 433-444
Manole, A., Kekilli, D., Svistunenko, DA., Wilson, MT., Dobbin, PS. and Hough, MA., (2015). . JBIC Journal of Biological Inorganic Chemistry. 20 (4), 675-686
Silaghi-Dumitrescu, R., Scurtu, F., Mason, MG., Svistunenko, DA., Wilson, MT. and Cooper, CE., (2015). . Inorganica Chimica Acta. 436, 179-183
Beckerson, P., Wilson, MT., Svistunenko, DA. and Reeder, BJ., (2015). . Biochemical Journal. 465 (1), 127-137
Bradley, JM., Svistunenko, DA., Lawson, TL., Hemmings, AM., Moore, GR. and Le鈥匓run, NE., (2015). Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin. Angewandte Chemie. 127 (49), 14976-14980
Bradley, JM., Svistunenko, DA., Lawson, TL., Hemmings, AM., Moore, GR. and Le鈥匓run, NE., (2015). . Angewandte Chemie International Edition. 54 (49), 14763-14767
Beckerson, P., Svistunenko, D. and Reeder, B., (2015). . F1000Research. 4, 87-87
Silaghi-Dumitrescu, R., Svistunenko, DA., Cioloboc, D., Bischin, C., Scurtu, F. and Cooper, CE., (2014). . Nitric Oxide: Biology and Chemistry. 42, 32-39
Ashe, D., Alleyne, T., Wilson, MT., Svistunenko, DA. and Nicholls, P., (2014). . Archives of Biochemistry and Biophysics. 554, 36-43
Cooper, CE., Schaer, DJ., Buehler, PW., Wilson, MT., Reeder, BJ., Silkstone, G., Svistunenko, DA., Bulow, L. and Alayash, AI., (2013). . Antioxidants & Redox Signaling. 18 (17), 2264-2273
Rajagopal, BS., Edzuma, AN., Hough, MA., Blundell, KLIM., Kagan, VE., Kapralov, AA., Fraser, LA., Butt, JN., Silkstone, GG., Wilson, MT., Svistunenko, DA. and Worrall, JAR., (2013). . Biochemical Journal. 456 (3), 441-452
Blundell, KLIM., Wilson, MT., Svistunenko, DA., Vijgenboom, E. and Worrall, JAR., (2013). . Open Biology. 3 (1), 120163-120163
Dumarieh, R., D'Antonio, J., Deliz-Liang, A., Smirnova, T., Svistunenko, DA. and Ghiladi, RA., (2013). . Journal of Biological Chemistry. 288 (46), 33470-33482
Blundell, KLIM., Wilson, MT., Svistunenko, DA., Vijgenboom, E. and Worrall, JAR., (2013). Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein.. Open biology. 3 (1)
Cooper, CE., Schaer, DJ., Buehler, PW., Wilson, MT., Reeder, BJ., Silkstone, G., Svistunenko, DA., Bulow, L. and Alayash, AI., (2013). Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine 尾145. Antioxidants & Redox Signaling. 18 (17), 2264-2273
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2012). . Journal of the American Chemical Society. 134 (18), 7741-7749
Svistunenko, DA., Worrall, JAR., Chugh, SB., Haigh, SC., Ghiladi, RA. and Nicholls, P., (2012). Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH. Biochimie. 94 (6), 1274-1280
Reeder, BJ., Svistunenko, DA. and Wilson, MT., (2011). . The Biochemical journal. 434 (3), 483-492
Svistunenko, DA., Adelusi, M., Dawson, M., Robinson, P., Bernini, C., Sinicropi, A. and Basosi, R., (2011). Computation informed selection of parameters for protein radical EPR spectra simulation. Studia Universitatis Babes-Bolyai Chemia. 56 (3), 135-146
Thompson, MK., Franzen, S., Ghiladi, RA., Reeder, BJ. and Svistunenko, DA., (2010). . Journal of the American Chemical Society. 132 (49), 17501-17510
Mot, A., Zoltan, K., Svistunenko, DA., Damian, G., Silaghi-Dumitrescu, R. and Makarov, SV., (2010). . Dalton Trans.. 39 (6), 1464-1466
Demidchik, V., Cuin, TA., Svistunenko, D., Smith, SJ., Miller, AJ., Shabala, S., Sokolik, A. and Yurin, V., (2010). . Journal of Cell Science. 123 (9), 1468-1479
Demidchik, V., Cuin, TA., Svistunenko, DA., Smith, SJ., Miller, AJ., Shabala, S., Sokolik, A. and Yurin, V., (2010). Arabidopsis root K(+)-efflux conductance activated by hydroxyl radicals: single-channel properties, genetic basis and involvement in stress-induced cell death. Journal of Cell Science. 123 (9), 1468-1479
Nicholls, P., Worrall, JAR. and Svistunenko, DA., (2010). . FEBS Journal. 277 (1), creators-Svistunenko=3ADimitri_A=3A=3A
Cooper, CE., Holladay, R., Nicholls, P., Svistunenko, DA., Mason, MG., Silkstone, G. and Wilson, MT., (2010). . Free Radical Biology And Medicine. 49 (1), creators-Wilson=3AMichael_T=3A=3A
Svistunenko, DA. and Jones, GA., (2009). . Physical Chemistry Chemical Physics. 11 (31), 6600-6600
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2009). Engineering Electron Transfer Pathways in Myoglobin and Hemoglobin: A Route to Detoxify Blood Substitutes?. Free Radical Biology And Medicine. 47, creators-Wilson=3AMichael_T=3A=3A
Reeder, BJ., Grey, M., Silaghi-Dumitrescu, R-L., Svistunenko, DA., B眉low, L., Cooper, CE. and Wilson, MT., (2008). . Journal of Biological Chemistry. 283 (45), 30780-30787
Chauhan, N., Basran, J., Efimov, I., Svistunenko, DA., Seward, HE., Moody, PCE. and Raven, EL., (2008). . Biochemistry. 47 (16), 4761-4769
Svistunenko, DA., Reeder, BJ., Wankasi, MM., Silaghi-Dumitrescu, R-L., Cooper, CE., Rinaldo, S., Cutruzzol?, F. and Wilson, MT., (2007). Reaction of Aplysia limacina metmyoglobin with hydrogen peroxide. Dalton Transactions (8), 840-840
Pipirou, Z., Bottrill, AR., Svistunenko, DA., Efimov, I., Basran, J., Mistry, SC., Cooper, CE. and Raven, EL., (2007). The Reactivity of Heme in Biological Systems:鈥 Autocatalytic Formation of Both Tyrosine鈭扝eme and Tryptophan鈭扝eme Covalent Links in a Single Protein Architecture. Biochemistry. 46 (46), 13269-13278
Svistunenko, DA., Davies, N., Brealey, D., Singer, M. and Cooper, CE., (2006). Mitochondrial dysfunction in patients with severe sepsis: An EPR interrogation of individual respiratory chain components. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757 (4), 262-272
Cooper, CE., Jurd, M., Nicholls, P., Wankasi, MM., Svistunenko, DA., Reeder, BJ. and Wilson, MT., (2005). On the formation, nature, stability and biological relevance of the primary reaction intermediates of myoglobins with hydrogen peroxide. Dalton Transactions (21), 3483-3483
Davies, NA., Brealey, DA., Stidwill, R., Singer, M., Svistunenko, DA. and Cooper, CE., (2005). Nitrosyl heme production compared in endotoxemic and hemorrhagic shock. Free Radical Biology and Medicine. 38 (1), 41-49
Papadopoulou, ND., Mewies, M., McLean, KJ., Seward, HE., Svistunenko, DA., Munro, AW. and Raven, EL., (2005). Redox and Spectroscopic Properties of Human Indoleamine 2,3-Dioxygenase and A His303Ala Variant:鈥 Implications for Catalysis. Biochemistry. 44 (43), 14318-14328
Kagan, VE., Tyurin, VA., Jiang, J., Tyurina, YY., Ritov, VB., Amoscato, AA., Osipov, AN., Belikova, NA., Kapralov, AA., Kini, V., Vlasova, II., Zhao, Q., Zou, M., Di, P., Svistunenko, DA., Kurnikov, IV. and Borisenko, GG., (2005). Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nature Chemical Biology. 1 (4), 223-232
Svistunenko, DA., (2005). Reaction of haem containing proteins and enzymes with hydroperoxides: The radical view. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1707 (1), 127-155
Silkstone, GG., Cooper, CE., Svistunenko, D. and Wilson, MT., (2005). EPR and Optical Spectroscopic Studies of Met80X Mutants of Yeast Ferricytochrome c. Models for Intermediates in the Alkaline Transition. Journal of the American Chemical Society. 127 (1), 92-99
Carlsson, GH., Nicholls, P., Svistunenko, D., Berglund, GI. and Hajdu, J., (2005). Complexes of Horseradish Peroxidase with Formate, Acetate, and Carbon Monoxide. Biochemistry. 44 (2), 635-642
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2004). The Radical and Redox Chemistry of Myoglobin and Hemoglobin: From In Vitro Studies to Human Pathology. Antioxidants & Redox Signaling. 6 (6), 954-966
Svistunenko, DA., Wilson, MT. and Cooper, CE., (2004). Tryptophan or tyrosine? On the nature of the amino acid radical formed following hydrogen peroxide treatment of cytochrome c oxidase. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1655 (1-3), 372-380
Svistunenko, DA. and Cooper, CE., (2004). A New Method of Identifying the Site of Tyrosyl Radicals in Proteins. Biophysical Journal. 87 (1), 582-595
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2004). The Radical and Redox Chemistry of Myoglobin and Hemoglobin: From<I> In Vitro</I> Studies to Human Pathology. Antioxidants and Redox Signaling. 6 (6), 954-966
Vanin, AF., Svistunenko, DA., Mikoyan, VD., Serezhenkov, VA., Fryer, MJ., Baker, NR. and Cooper, CE., (2004). Endogenous Superoxide Production and the Nitrite/Nitrate Ratio Control the Concentration of Bioavailable Free Nitric Oxide in Leaves. Journal of Biological Chemistry. 279 (23), 24100-24107
Malone, SA., Lewin, A., Kilic, MA., Svistunenko, DA., Cooper, CE., Wilson, MT., Le Brun, NE., Spiro, S. and Moore, GR., (2004). Protein-Template-Driven Formation of Polynuclear Iron Species. Journal of the American Chemical Society. 126 (2), 496-504
(2004). Correction. Biophysical Journal. 87 (5), 3614-3616
Svistunenko, DA., Reeder, BJ., Wilson, MT. and Cooper, CE., (2003). Radical Formation and Migration in Myoglobins. Progress in Reaction Kinetics and Mechanism. 28 (1), 105-118
Murphy, MP., Echtay, KS., Blaikie, FH., Asin-Cayuela, J., Cochem茅, HM., Green, K., Buckingham, JA., Taylor, ER., Hurrell, F., Hughes, G., Miwa, S., Cooper, CE., Svistunenko, DA., Smith, RAJ. and Brand, MD., (2003). Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation. Journal of Biological Chemistry. 278 (49), 48534-48545
McHugh, JP., Rodr铆guez-Qui帽ones, F., Abdul-Tehrani, H., Svistunenko, DA., Poole, RK., Cooper, CE. and Andrews, SC., (2003). Global Iron-dependent Gene Regulation in Escherichia coli. Journal of Biological Chemistry. 278 (32), 29478-29486
Svistunenko, DA., Dunne, J., Fryer, M., Nicholls, P., Reeder, BJ., Wilson, MT., Bigotti, MG., Cutruzzol脿, F. and Cooper, CE., (2002). Comparative Study of Tyrosine Radicals in Hemoglobin and Myoglobins Treated with Hydrogen Peroxide. Biophysical Journal. 83 (5), 2845-2855
Reeder, BJ., Svistunenko, DA., Sharpe, MA. and Wilson, MT., (2002). Characteristics and Mechanism of Formation of Peroxide-Induced Heme to Protein Cross-Linking in Myoglobin. Biochemistry. 41 (1), 367-375
Torres, J., Svistunenko, D., Karlsson, B., Cooper, CE. and Wilson, MT., (2002). Fast Reduction of a Copper Center in Laccase by Nitric Oxide and Formation of a Peroxide Intermediate. Journal of the American Chemical Society. 124 (6), 963-967
Svistunenko, DA., (2001). An EPR study of the peroxyl radicals induced by hydrogen peroxide in the haem proteins. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1546 (2), 365-378
SVISTUNENKO, DA., SHARPE, MA., NICHOLLS, P., BLENKINSOP, C., DAVIES, NA., DUNNE, J., WILSON, MT. and COOPER, CE., (2000). The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study. Biochemical Journal. 351 (3), 595-605
Svistunenko, DA., Sharpe, MA., Nicholls, P., Wilson, MT. and Cooper, CE., (2000). A New Method for Quantitation of Spin Concentration by EPR Spectroscopy: Application to Methemoglobin and Metmyoglobin. Journal of Magnetic Resonance. 142 (2), 266-275
Silver, J., Marsh, PJ., Symons, MCR., Svistunenko, DA., Frampton, CS. and Fern, GR., (2000). Crystal Structure of Bis(4-methylimidazole)tetraphenylporphyrinatoiron(III) Chloride and Related Compounds. Correlation of Ground State with Fe鈭扤 Bond Lengths. Inorganic Chemistry. 39 (13), 2874-2881
Silver, J., Marsh, PJ., Symons, MCR., Svistunenko, DA., Frampton, CS. and Fern, GR., (2000). Crystal structure of bis(4-methylimidazole) tetraphenylporphyrinatoiron(III) chloride and related compounds. Correlation of ground state with Fe-N bond lengths. INORGANIC CHEMISTRY. 39 (13), 2874-2881
SVISTUNENKO, DA., SHARPE, MA., NICHOLLS, P., BLENKINSOP, C., DAVIES, NA., DUNNE, J., WILSON, MT. and COOPER, CE., (2000). The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study. Biochemical Journal. 351 (3), 595-595
Svistunenko, DA., Rob, A., Ball, A., Torres, J., Symons, MCR., Wilson, MT. and Cooper, CE., (1999). The electron paramagnetic resonance characterisation of a copper-containing extracellular peroxidase from Thermomonospora fusca BD25. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1434 (1), 74-85
Dunne, J., Svistunenko, DA., Wilson, MT., Alayash, AI. and Cooper, CE., (1998). Reactions of cross-linked ferric haemoglobins with hydrogen peroxide. Biochemical Society Transactions. 26 (4), 9-15
Dunne, J., Svistunenko, DA., Wilson, MT., Alayash, AI. and Cooper, CE., (1998). 20 Reactions of cross-linked ferric haemoglobins with hydrogen peroxide. Biochemical Society Transactions. 26 (4), S320-S320
Cooper, CE., Torres, J., Sharpe, MA., Wilson, MT. and Svistunenko, DA., (1998). Peroxynitrite Reacts with Methemoglobin to Generate Globin-Bound Free Radical Species. Advances in Experimental Medicine and Biology. 454, 195-202
Moore, KP., Holt, SG., Patel, RP., Svistunenko, DA., Zackert, W., Goodier, D., Reeder, BJ., Clozel, M., Anand, R., Cooper, CE., Morrow, JD., Wilson, MT., Darley-Usmar, V. and Roberts, LJ., (1998). A Causative Role for Redox Cycling of Myoglobin and Its Inhibition by Alkalinization in the Pathogenesis and Treatment of Rhabdomyolysis-induced Renal Failure. Journal of Biological Chemistry. 273 (48), 31731-31737
Svistunenko, DA., Patel, RP., Voloshchenko, SV. and Wilson, MT., (1997). The Globin-based Free Radical of Ferryl Hemoglobin Is Detected in Normal Human Blood. Journal of Biological Chemistry. 272 (11), 7114-7121
PATEL, RP., SVISTUNENKO, D., WILSON, MT. and DARLEY-USMAR, VM., (1997). Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein. Biochemical Journal. 322 (2), 425-433
Svistunenko, DA., Patel, RP. and Wilson, MT., (1996). An EPR Investigation of Human Methaemoglobin Oxidation by Hydrogen Peroxide: Methods to Quantify all Paramagnetic Species Observed in the Reaction. Free Radical Research. 24 (4), 269-280
Patel, RP., Svistunenko, DA., Darley-usmar, VM., Symons, MCR. and Wilson, MT., (1996). Redox Cycling of Human Methaemoglobin by H2O2Yields Persistent Ferryl Iron and Protein Based Radicals. Free Radical Research. 25 (2), 117-123
Symons, MCR., Taiwo, FA. and Svistunenko, DA., (1993). Electron paramagnetic resonance studies of hole mobility and localisation in haemoglobin. Journal of the Chemical Society, Faraday Transactions. 89 (16), 3071-3071
Boulton, M., Dontsov, A., Jarvis-Evans, J., Ostrovsky, M. and Svistunenko, D., (1993). Lipofuscin is a photoinducible free radical generator. Journal of Photochemistry and Photobiology B: Biology. 19 (3), 201-204
Svistunenko, DA., (1991). The decomposition of the EPR spectra of multicomponent systems irradiated at 77 K into paramagnetic center signals of different natures. Izevestiya Akademii Nauk SSSR - Seriya Biologicheskaya (4), 540-557
SVISTUNENKO, DA., (1991). THE DECOMPOSITION OF AN EPR-SPECTRUM OF A MULTICOMPONENT SYSTEM, IRRADIATED AT 77-K, INTO DIFFERENT PARAMAGNETIC CENTER SIGNALS. IZVESTIYA AKADEMII NAUK SSSR SERIYA BIOLOGICHESKAYA (4), 540-557
Svistunenko, DA., (1990). [Ascorbic acid radicals induced by the action of radiation in tissues from rat organs frozen at 77 K].. Izvestiia Akademii nauk SSSR. Seriia biologicheskaia (6), 827-834
Svistunenko, DA., (1990). Ascorbic acid radicals induced by radiation in frozen at 77 K rat tissues. Izevestiya Akademii Nauk SSSR - Seriya Biologicheskaya (6), 827-834
Svistunenko, DA. and Gudtsova, KV., (1989). Modification by cystamine of radiation-induced free radical damages to biomolecules in tissues of mouse organs. Radiobiologiya. 29 (1), 3-7
JURCZYK, MU., SVISTUNENKO, DA., KUDRYAVTSEV, ME. and KUROPTEVA, ZV., (1989). ASCORBIC-ACID RADICALS INDUCED BY RADIATION IN TUMOR-TISSUES. STUDIA BIOPHYSICA. 133 (1), 19-24
Svistunenko, DA., Kosaganova, NI. and Kopylovski沫, SA., (1986). [Paramagnetic centers formed in mouse blood gamma-irradiated at 77K].. Radiobiologiia. 26 (1), 28-34
Svistunenko, DA., Rikhireva, GT. and Pulatova, MK., (1986). Radiation-induced free radicals of DNA, DNA content in tissues, and tissue radiosensitivity. Radiobiologiya. 26 (1), 22-27
Svistunenko, DA., Kosaganova Yu., N. and Kopylovsky, SA., (1986). Paramagnetic centres formed in mouse blood after 纬-irradiation at 77 K. Radiobiologiya. 26 (1), 28-34
Svistunenko, DA., Rikhireva, GT., Pulatova, MK. and Ermakov, VM., (1984). Free-radical disorders in the tissues of mice exposed to gamma irradiation and neutrons in vitro. The radiochemical yields. Radiobiologiya. 24 (1), 3-8
Conferences (5)
Thompson, MK., Franzen, S., Ghiladi, RA., Reeder, BJ. and Svistunenko, DA., (2011). Decay of Compound ES in Dehaloperoxidase-Hemoglobin
Reeder, BJ., Svistunenko, DA., Cooper, CE. and Wilson, MT., (2009).
Dunne, J., Svistunenko, DA., Alayash, AI., Wilson, MT. and Cooper, CE., (1999). Increased free radical formation by hemoglobin based oxygen carriers.
Dunne, J., Svistunenko, DA., Alayash, AI., Wilson, MT. and Cooper, CE., (1999). Reactions of Cross-Linked Methaemoglobins with Hydrogen Peroxide
A. Svistunenko, D., A. Davies, N., T. Wilson, M., P. Stidwill, R., Singer, M. and E. Cooper, C., (1997). Free radical in blood: a measure of haemoglobin autoxidation in vivo?鈥娾
Grants and funding
2024
Creating and comprehending the circuitry of life: precise biomolecular design of multi-centre redox enzymes for a synthetic metabolism
Biotechnology and Biological Sciences Research Council
2023
TRICSS - a multi-user high-throughput platform to quantify biological interactions in solution
Biotechnology and Biological Sciences Research Council
TRICSS - a multi-user high-throughput platform to quantify biological interactions in solution
Biotechnology and Biological Sciences Research Council
2022
Why bacterioferritins in pathogenic bacteria have haem co-factors
The Royal Society
2020
Replacement EPR spectrometer to the multiuser Biomedical EPR Facility at the 糖心Vlog
Biotechnology and Biological Sciences Research Council
2017
Mechanistic studies of mitochondrial ferritin
Biotechnology & Biology Science Res.Council
2009
EPR Study of Haptoglobin Binding
The Royal Society
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