Professor Jonathan Worrall
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Email
jworrall@essex.ac.uk -
Telephone
+44 (0) 1206 872095
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Location
3SW.5.23, Colchester Campus
Profile
Biography
2007-present: 糖心Vlog, UK 2005-2007: Post-doctoral research associate, Department of Biochemistry, University of Cambridge, UK 1999-2005: Post-doctoral research associate, Leiden Institute of Chemistry, Leiden University, The Netherlands 1995-1999: PhD in Bioinorganic Chemistry, Department of Chemistry, Newcastle University, UK 1992-1995: BSc (Hons) Medicinal Chemistry, Newcastle University, UK Local Ambassador for the Biochemical Society Secretary of the Inorganic Biochemistry Discussion Group, (Royal Society of Chemistry)
Research and professional activities
Research interests
Microbial Biotechnology
Copper homeostasis in Streptomyces
Lipid induced apoptosis
Structural Biochemistry
Current research
My research focus is on the role of metal ions and metalloproteins in biology.
Copper and StreptomycesWe are interested in the role of copper on the morphological development of the antibiotic producing actinobacterium Streptomyces lividans. Using microbial genetics, structural biology, spectroscopy and RNA-seq analysis we have identified and characterised copper sensing and trafficking pathways leading to the metallation of cuproenzymes that are critical for initiating development in this industrially important microbe.
Mitochondrial cytochrome c and apoptosisThe haem containing redox protein cytochrome c is a key mitochondrial protein that plays an important role in the life and death decisions of a cell. In the mitochondrial apoptosis pathway cytochrome c is released from the mitochondria into the cytosol leading to the formation of the apoptosome assembly, a cellular platform to initiate caspase activity triggering cell death. The selective oxidation by cytochorme c of a unique inner-membrane mitochondrial phospholipid, diphosphatidylglycerol, better known as cardiolipin has been demonstrated to trigger events that lead to cytochrome c release from the mitochondria. Using NMR and EPR spectroscopies we are investigating the interaction and complex formed bewteen cytochorme c and cardiolipin.
Teaching and supervision
Current teaching responsibilities
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Transferable Skills in Life Sciences (BS143)
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Metals in Biotechnology (BS228)
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Structural and Molecular Enzymology (BS314)
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Research Project in Life Sciences (BS832)
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Industrial Biotechnology (BS937)
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Research Project in Biomedical Science (BS831)
Previous supervision
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 26/6/2024
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 16/2/2024
Degree subject: Biochemistry
Degree type: Master of Science (by Dissertation)
Awarded date: 29/6/2023
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 7/2/2022
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 5/7/2019
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 25/6/2018
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 23/3/2016
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 21/3/2016
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 8/5/2014
Degree subject: Biochemistry
Degree type: Doctor of Philosophy
Awarded date: 12/2/2013
Publications
Journal articles (79)
Williams, LJ., Thompson, AJ., Dijkstal, P., Appleby, M., Assmann, G., Dworkowski, FSN., Hiller, N., Huang, C-Y., Mason, T., Perrett, S., Prat, E., Voulot, D., Pedrini, B., Beale, JH., Hough, MA., Worrall, JAR. and Owen, RL., (2025). Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography. IUCrJ. 12 (3), 358-371
Thompson, AJ., Sanchez-Weatherby, J., Williams, LJ., Mikolajek, H., Sandy, J., Worrall, JAR. and Hough, MA., (2024). Efficient in situ screening of and data collection from microcrystals in crystallization plates. Acta Crystallographica Section D Structural Biology. 80 (4), 279-288
Bolton, R., Machelett, MM., Worrall, JAR., Hough, MA. and et al., (2024). . Proceedings of the National Academy of Sciences of the United States of America. 121 (12), e2308478121-
Lu膷i膰, M., Allport, T., Clarke, TA., Williams, LJ., Wilson, MT., Chaplin, AK. and Worrall, JAR., (2024). . Protein Science. 33 (7), e5073-
Prischi, F., Birrell, JA., Carroni, M. and Worrall, J., (2024). Meeting Reports. The Biochemist. 46 (5), 50-50
Hough, MA., Prischi, F. and Worrall, JAR., (2023). Perspective: Structure determination of protein-ligand complexes at room temperature using X-ray diffraction approaches. Frontiers in Molecular Biosciences. 10, 1113762-
Lu膷i膰, M., Wilson, MT., Pullin, J., Hough, MA., Svistunenko, DA. and Worrall, JAR., (2023). New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase. Chemical Science. 14 (44), 12518-12534
Moreno-Chicano, T., Carey, LM., Axford, D., Beale, JH., Doak, RB., Duyvesteyn, HME., Ebrahim, A., Henning, RW., Monteiro, DCF., Myles, DA., Owada, S., Sherrell, DA., Straw, ML., 艩rajer, V., Sugimoto, H., Tono, K., Tosha, T., Tews, I., Trebbin, M., Strange, RW., Weiss, KL., Worrall, JAR., Meilleur, F., Owen, RL., Ghiladi, RA. and Hough, MA., (2022). . IUCrJ. 9 (5), 610-624
Worrall, JAR. and Hough, MA., (2022). . Current Opinion in Structural Biology. 77, 102486-102486
Lu膷i膰, M., Wilson, MT., Tosha, T., Sugimoto, H., Shilova, A., Axford, D., Owen, RL., Hough, MA. and Worrall, JAR., (2022). . ACS Catalysis. 12 (21), 13349-13359
Munir, A., Wilson, MT., Hardwick, SW., Chirgadze, DY., Worrall, JAR., Blundell, TL. and Chaplin, AK., (2021). . Structure. 29 (8), 899-912.e4
Pullin, J., Wilson, MT., Cl茅mancey, M., Blondin, G., Bradley, JM., Moore, GR., Le Brun, NE., Lu膷i膰, M., Worrall, JAR. and Svistunenko, DA., (2021). . Angewandte Chemie International Edition. 60 (15), 8361-8369
Lu膷i膰, M., Wilson, MT., Svistunenko, DA., Owen, RL., Hough, MA. and Worrall, JAR., (2021). . Journal of Biological Inorganic Chemistry. 26 (7), 743-761
Horrell, S., Axford, D., Devenish, NE., Ebrahim, A., Hough, MA., Sherrell, DA., Storm, SLS., Tews, I., Worrall, JAR. and Owen, RL., (2021). . Journal of Visualized Experiments. 2021 (168)
Deacon, OM., White, RW., Moore, GR., Wilson, MT. and Worrall, JAR., (2020). . Journal of Inorganic Biochemistry. 203, 110924-110924
Lucic, M., Chaplin, AK., Moreno-Chicano, T., Dworkowski, F., Wilson, M., Svistunenko, D., Hough, M. and Worrall, JAR., (2020). . Dalton Transactions. 49 (5), 1620-1636
Lucic, M., Svistunenko, D., Wilson, M., Chaplin, A., Davy, B., Ebrahim, A., Axford, D., Tosha, T., Sugimoto, H., Owada, S., Dworkowski, F., Tews, I., Owen, R., Hough, M. and Worrall, JAR., (2020). . Angewandte Chemie International Edition. 59 (48), 21656-21662
Lu膷i膰, M., Svistunenko, DA., Wilson, MT., Chaplin, AK., Davy, B., Ebrahim, A., Axford, D., Tosha, T., Sugimoto, H., Owada, S., Dworkowski, FSN., Tews, I., Owen, RL., Hough, MA. and Worrall, JAR., (2020). Serial Femtosecond Zero Dose Crystallography Captures a Water鈥怓ree Distal Heme Site in a Dye鈥怐ecolorising Peroxidase to Reveal a Catalytic Role for an Arginine in FeIV=O Formation. Angewandte Chemie. 132 (48), 21840-21846
Chaplin, AK., Chicano, TM., Hampshire, BV., Wilson, MT., Hough, MA., Svistunenko, DA. and Worrall, JAR., (2019). . Chemistry 鈥� A European Journal. 25 (24), 6141-6153
Straw, ML., Hough, MA., Wilson, MT. and Worrall, JAR., (2019). . Chemistry 鈥� A European Journal. 25 (45), 10678-10688
Ebrahim, A., Moreno-Chicano, T., Appleby, MV., Chaplin, AK., Beale, JH., Sherrell, DA., Duyvesteyn, HME., Owada, S., Tono, K., Sugimoto, H., Strange, RW., Worrall, JAR., Axford, D., Owen, RL. and Hough, MA., (2019). . IUCrJ. 6 (4), 543-551
Moreno-Chicano, T., Ebrahim, A., Axford, D., Appleby, MV., Beale, JH., Chaplin, AK., Duyvesteyn, HME., Ghiladi, RA., Owada, S., Sherrell, DA., Strange, RW., Sugimoto, H., Tono, K., Worrall, JAR., Owen, RL. and Hough, MA., (2019). . IUCrJ. 6 (6), 1074-1085
Beale, JH., Bolton, R., Marshall, SA., Beale, EV., Carr, SB., Ebrahim, A., Moreno-Chicano, T., Hough, MA., Worrall, JAR., Tews, I. and Owen, RL., (2019). . Journal of Applied Crystallography. 52 (6), 1385-1396
Straw, ML., Chaplin, AK., Hough, MA., Paps, J., Bavro, VN., Wilson, MT., Vijgenboom, E. and Worrall, JAR., (2018). . Metallomics: integrated biometal science. 2018 (10), 180-193
Deacon, OM., Svistunenko, DA., Moore, GR., Wilson, MT. and Worrall, JAR., (2018). . Biochemistry. 57 (29), 4276-4288
Chaplin, AK., Svistunenko, DA., Hough, MA., Wilson, MT., Vijgenboom, E. and Worrall, JAR., (2017). . The Biochemical Journal. 474 (5), 809-825
Karsisiotis, AI., Deacon, OM., Macdonald, C., Blumenschein, TMA., Moore, GR. and Worrall, JAR., (2017). . Biomolecular NMR Assignments. 11 (2), 165-168
Chaplin, AK., Bernini, C., Sinicropi, A., Basosi, R., Worrall, JAR. and Svistunenko, DA., (2017). . Angewandte Chemie International Edition. 129 (23), 6602-6606
Kekilli, D., Moreno-Chicano, T., Chaplin, AK., Horrell, S., Dworkowski, FSN., Worrall, JAR., Strange, RW. and Hough, MA., (2017). . IUCrJ. 4 (3), 263-270
Chaplin, AK., Wilson, MT. and Worrall, JAR., (2017). . Dalton Transactions. 46 (29), 9420-9429
Deacon, OM., Karsisiotis, AI., Moreno-Chicano, T., Hough, MA., Macdonald, C., Blumenschein, TMA., Wilson, MT., Moore, GR. and Worrall, JAR., (2017). . Biochemistry. 56 (46), 6111-6124
Chaplin, AK., Bernini, C., Sinicropi, A., Basosi, R., Worrall, JAR. and Svistunenko, DA., (2017). Tyrosine or Tryptophan? Modifying a Metalloradical Catalytic Site by Removal of the Cys鈥揟yr Cross鈥怢ink in the Galactose 6鈥怬xidase Homologue GlxA. Angewandte Chemie. 129 (23), 6602-6606
Chaplin, AK., Wilson, MT., Hough, MA., Svistunenko, DA., Hemsworth, GR., Walton, PH., Vijgenboom, E. and Worrall, JAR., (2016). . Journal of Biological Chemistry. 291 (24), 12838-12850
Petrus, MLC., Vijgenboom, E., Chaplin, AK., Worrall, JAR., van Wezel, GP. and Claessen, D., (2016). . Open Biology. 6 (1), 150149-150149
Karsisiotis, AI., Deacon, OM., Wilson, MT., Macdonald, C., Blumenschein, TMA., Moore, GR. and Worrall, JAR., (2016). . Scientific Reports. 6 (1), 30447-
Chaplin, AK., Tan, BG., Vijgenboom, E. and Worrall, JAR., (2015). . Metallomics. 7 (1), 145-155
Chaplin, AK., Petrus, MLC., Mangiameli, G., Hough, MA., Svistunenko, DA., Nicholls, P., Claessen, D., Vijgenboom, E. and Worrall, JAR., (2015). . Biochemical Journal. 469 (3), 433-444
Porto, TV., Hough, MA. and Worrall, JAR., (2015). . Acta Crystallographica Section D Biological Crystallography. 71 (9), 1872-1878
Karsisiotis, AI., Deacon, OM., Rajagopal, BS., Macdonald, C., Blumenschein, TMA., Moore, GR. and Worrall, JAR., (2015). . Biomolecular NMR Assignments. 9 (2), 415-419
Porto, TV., Wilson, MT. and Worrall, JAR., (2015). . Dalton Transactions. 44 (46), 20176-20185
Hough, MA., Silkstone, G., Worrall, JAR. and Wilson, MT., (2014). . NITRIC OXIDE. 96, 193-209
Blundell, KLIM., Hough, MA., Vijgenboom, E. and Worrall, JAR., (2014). . Biochemical Journal. 459 (3), 525-538
Tan, BG., Vijgenboom, E. and Worrall, JAR., (2014). . Nucleic Acids Research. 42 (2), 1326-1340
Rajagopal, BS., Edzuma, AN., Hough, MA., Blundell, KLIM., Kagan, VE., Kapralov, AA., Fraser, LA., Butt, JN., Silkstone, GG., Wilson, MT., Svistunenko, DA. and Worrall, JAR., (2013). . Biochemical Journal. 456 (3), 441-452
Blundell, KLIM., Wilson, MT., Svistunenko, DA., Vijgenboom, E. and Worrall, JAR., (2013). . Open Biology. 3 (1), 120163-120163
Blundell, KLIM., Wilson, MT., Vijgenboom, E. and Worrall, JAR., (2013). . Dalton Transactions. 42 (29), 10608-10608
Dwarakanath, S., Chaplin, AK., Hough, MA., Rigali, S., Vijgenboom, E. and Worrall, JAR., (2012). . Journal of Biological Chemistry. 287 (21), 17833-17847
Svistunenko, DA., Worrall, JAR., Chugh, SB., Haigh, SC., Ghiladi, RA. and Nicholls, P., (2012). Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH. Biochimie. 94 (6), 1274-1280
Mason, JM., Bendall, DS., Howe, CJ. and Worrall, JAR., (2012). . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1824 (2), 311-318
Rajagopal, BS., Silkstone, GG., Nicholls, P., Wilson, MT. and Worrall, JAR., (2012). . Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817 (5), 780-791
Bischin, C., Deac, F., Silaghi-Dumitrescu, R., Worrall, JAR., Rajagopal, BS., Damian, G. and Cooper, CE., (2011). . Free Radical Research. 45 (4), 439-444
Worrall, JAR. and Mason, JM., (2011). . FEBS Journal. 278 (4), 663-672
Rajagopal, BS., Wilson, MT., Bendall, DS., Howe, CJ. and Worrall, JAR., (2011). . JBIC Journal of Biological Inorganic Chemistry. 16 (4), 577-588
Volkov, AN., Nicholls, P. and Worrall, JAR., (2011). The complex of cytochrome c and cytochrome c peroxidase: The end of the road?. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1807 (11), 1482-1503
Worrall, JAR. and Vijgenboom, E., (2010). . Natural Product Reports. 27 (5), 742-742
Volkov, AN., Bashir, Q., Worrall, JAR., Ullmann, GM. and Ubbink, M., (2010). . Journal of the American Chemical Society. 132 (33), 11487-11495
Volkov, AN., Bashir, Q., Worrall, JAR. and Ubbink, M., (2009). . Journal of Molecular Biology. 385 (3), 1003-1013
Worrall, JAR., G贸rna, M., Crump, NT., Phillips, LG., Tuck, AC., Price, AJ., Bavro, VN. and Luisi, BF., (2008). . Journal of Molecular Biology. 382 (4), 870-883
Worrall, JAR., Howe, FS., McKay, AR., Robinson, CV. and Luisi, BF., (2008). . Journal of Biological Chemistry. 283 (9), 5567-5576
Worrall, JAR., Luisi, BF., Schlarb-Ridley, BG., Bendall, DS. and Howe, CJ., (2008). . Biochemical Society Transactions. 36 (6), 1175-1179
Worrall, JAR. and Luisi, BF., (2007). Information available at cut rates: structure and mechanism of ribonucleases. Current Opinion in Structural Biology. 17 (1), 128-137
Worrall, JAR., G贸rna, M., Pei, XY., Spring, DR., Nicholson, RL. and Luisi, BF., (2007). Design and chance in the self-assembly of macromolecules. Biochemical Society Transactions. 35 (3), 502-507
Worrall, JAR., Schlarb-Ridley, BG., Reda, T., Marcaida, MJ., Moorlen, RJ., Wastl, J., Hirst, J., Bendall, DS., Luisi, BF. and Howe, CJ., (2007). Modulation of Heme Redox Potential in the Cytochrome c6 Family. Journal of the American Chemical Society. 129 (30), 9468-9475
Volkov, AN., Worrall, JAR., Holtzmann, E. and Ubbink, M., (2006). Solution structure and dynamics of the complex between cytochromecand cytochromecperoxidase determined by paramagnetic NMR. Proceedings of the National Academy of Sciences. 103 (50), 18945-18950
Marcaida, MJ., Schlarb-Ridley, BG., Worrall, JAR., Wastl, J., Evans, TJ., Bendall, DS., Luisi, BF. and Howe, CJ., (2006). Structure of Cytochrome c6A, a Novel Dithio-cytochrome of Arabidopsis thaliana, and its Reactivity with Plastocyanin: Implications for Function. Journal of Molecular Biology. 360 (5), 968-977
Worrall, JAR., Machczynski, MC., Keijser, BJF., di Rocco, G., Ceola, S., Ubbink, M., Vijgenboom, E. and Canters, GW., (2006). Spectroscopic Characterization of a High-Potential Lipo-Cupredoxin Found in Streptomyces coelicolor. Journal of the American Chemical Society. 128 (45), 14579-14589
(2006). CORRECTION. Protein Science. 15 (6), 1563-1563
Volkov, AN., Ferrari, D., Worrall, JAR., Bonvin, AMJJ. and Ubbink, M., (2006). The orientations of cytochrome c in the highly dynamic complex with cytochrome b5 visualized by NMR and docking using HADDOCK (vol 14, pg 799, 2005). PROTEIN SCIENCE. 15 (6), 1563-1563
Worrall, JAR., van Roon, AM., Ubbink, M. and Canters, GW., (2005). The effect of replacing the axial methionine ligand with a lysine residue in cytochrome鈥�c鈥�550 from Paracoccus versutus assessed by X鈥恟ay crystallography and unfolding. The FEBS Journal. 272 (10), 2441-2455
Volkov, AN., Ferrari, D., Worrall, JAR., Bonvin, AMJJ. and Ubbink, M., (2005). The orientations of cytochrome c in the highly dynamic complex with cytochrome b5 visualized by NMR and docking using HADDOCK. Protein Science. 14 (3), 799-811
Worrall, JAR., Diederix, REM., Prud锚ncio, M., Lowe, CE., Ciofi鈥怋affoni, S., Ubbink, M. and Canters, GW., (2005). The Effects of Ligand Exchange and Mobility on the Peroxidase Activity of a Bacterial Cytochrome c upon Unfolding. ChemBioChem. 6 (4), 747-758
Diederix, REM., Fittipaldi, M., Worrall, JAR., Huber, M., Ubbink, M. and Canters, GW., (2003). Kinetic Stability of the Peroxidase Activity of Unfolded Cytochrome c:鈥� Heme Degradation and Catalyst Inactivation by Hydrogen Peroxide. Inorganic Chemistry. 42 (22), 7249-7257
Worrall, JAR., Reinle, W., Bernhardt, R. and Ubbink, M., (2003). Transient Protein Interactions Studied by NMR Spectroscopy:鈥� The Case of Cytochrome c and Adrenodoxin. Biochemistry. 42 (23), 7068-7076
Crowley, PB., Rabe, KS., Worrall, JAR., Canters, GW. and Ubbink, M., (2002). The Ternary Complex of Cytochrome f and Cytochrome c: Identification of a Second Binding Site and Competition for Plastocyanin Binding. ChemBioChem. 3 (6), 526-526
Ubbink, M., Worrall, JAR., Canters, GW., Groenen, EJJ. and Huber, M., (2002). Paramagnetic Resonance of Biological Metal Centers. Annual Review of Biophysics and Biomolecular Structure. 31 (1), 393-422
Worrall, JAR., Liu, Y., Crowley, PB., Nocek, JM., Hoffman, BM. and Ubbink, M., (2002). Myoglobin and Cytochrome b5:鈥� A Nuclear Magnetic Resonance Study of a Highly Dynamic Protein Complex. Biochemistry. 41 (39), 11721-11730
Crowley, PB., Rabe, KS., Worrall, JAR., Canters, GW. and Ubbink, M., (2002). The ternary complex of cytochrome f and cytochrome c: Identification of a second binding site and competition for plastocyanin binding. ChemBioChem. 3 (6), 526-533
Worrall, JAR., Kolczak, U., Canters, GW. and Ubbink, M., (2001). Interaction of Yeast Iso-1-cytochrome c with Cytochrome c Peroxidase Investigated by [15N,1H] Heteronuclear NMR Spectroscopy. Biochemistry. 40 (24), 7069-7076
Im, S-C., Worrall, JAR., Liu, G., Aliverti, A., Zanetti, G., Luchinat, C., Bertini, I. and Sykes, AG., (2000). The CrIIL Reduction of [2Fe-2S] Ferredoxins and Site of Attachment of CrIII Using 1H NMR and Site-Directed Mutagenesis. Inorganic Chemistry. 39 (8), 1755-1764
Book chapters (1)
Worrall, JAR., (2021). . In: Encyclopedia of Inorganic and Bioinorganic Chemistry (EIBC). Editors: Scott, RA., . Wiley. 1- 16. 9781119951438
Conferences (3)
Karsisiotis, AI., Deacon, OM., Wilson, MT., Macdonald, C., Blumenschein, TMA., Moore, GR. and Worrall, JAR., (2017). The G41S Variant of Human Cytochrome C Enhances Apoptosis via Increased Dynamics
Ubbink, M., Crowley, PB. and Worrall, JAR., (2001). Dynamics of electron transfer protein complexes probed by NMR
Worrall, JAR., Volkov, A., Canters, GW. and Ubbink, M., (2001). Heme protein-protein interactions studied by NMR
Grants and funding
2023
A holistic approach to reaction initiation at XFEL and synchrotron facilities
Biotechnology and Biological Sciences Research Council
TRICSS - a multi-user high-throughput platform to quantify biological interactions in solution
Biotechnology and Biological Sciences Research Council
TRICSS - a multi-user high-throughput platform to quantify biological interactions in solution
Biotechnology and Biological Sciences Research Council
2021
Proton management in the stabilisation of tyrosyl radicals in peroxidases
Royal Society of Chemistry
Breaking the Cage: Transformative Time-resolved Crystallography using Fixed Targets at Synchrotrons and XFELs
Biotechnology and Biological Sciences Research Council
Breaking the Cage: Transformative Time-resolved Crystallography using Fixed Targets at Synchrotrons and XFELs
Biotechnology and Biological Sciences Research Council
Breaking the Cage: Transformative Time-resolved Crystallography using Fixed Targets at Synchrotrons and XFELs
Biotechnology and Biological Sciences Research Council
2020
Replacement EPR spectrometer to the multiuser Biomedical EPR Facility at the 糖心Vlog
Biotechnology and Biological Sciences Research Council
2019
Protein Detection Kit
East Suffolk and North 糖心Vlog NHS Foundation Trust
2018
High hit-rate, high-throughput serial protein crystallography at SACLA using fixed target silicon nitride chips
Biotechnology and Biological Sciences Research Council
2017
The role of carbohydrate binding modules appended to lytic polysaccharide monooxygenases on substrate binding
Biochemical Society
The role of carbohydrate binding modules appended to lytic polysaccharide monooxygenases on substrate binding
Biochemical Society
Creating new starch active copper LPMOs through the generation of loop libraries
Biotechnology and Biological Sciences Research Council
2013
Characterisation of a protein bound free radical induced by hydrogen peroxide
Wellcome Trust
Fat(al) attraction of cytochrome c: A new approach to study protein-lipid interaction
Leverhulme Trust
2012
Elucidating the maturation pathway of a cuproenzyme proposed to be critical for motphological development in Steptomyces lividans
Society of Biology
2011
Summer Vacation Studentship - Amanda Chaplin
Biochemical Society
2008
Protein Interactions Between A Dead-Box
The Royal Society
